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Research Resources: Analytic Conventions - Model Description (Liver)

Model Descriptions on This Page

Graft Survival Model Description

Adult (Age 18+)

Pediatric (Age 0-17)

Patient Survival Model Description

Adult (Age 18+)

Pediatric (Age 0-17)

Graft Survival Model Description
1 Month after Transplant
Organ: Liver
Adult (Age 18+)

94.8% alive at 1 Month when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	0.0426	0.1021	0.6761
ABO compatibility: incompatible (ref=equal)	0.3643	0.2835	0.1988
ABO compatibility: unknown (ref=equal)	-6.5874	126.1333	0.9583
Creatinine > 2	0.3472	0.0901	0.0001
Diagnosis: AHN*	0.1876	0.1067	0.0787
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	0.0672	0.1055	0.5241
Diagnosis: Malignant Neoplasms*	0.2593	0.1590	0.1029
Diagnosis: Metabolic Diseases*	0.0678	0.1938	0.7264
Diagnosis: Other/Missing*	0.1386	0.1299	0.2860
Donor age: 0-17 (ref=35-49)	0.0211	0.1300	0.8712
Donor age: 18-34 (ref=35-49)	0.0078	0.0933	0.9331
Donor age: 50-64 (ref=35-49)	0.1493	0.0932	0.1091
Donor age: 65+ (ref=35-49)	0.3282	0.1228	0.0075
Donor female	0.1684	0.0684	0.0138
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	0.3459	0.2957	0.2422
Donor: cadaveric COD anoxia (ref=COD Head trauma)	0.1533	0.1296	0.2367
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.0821	0.0913	0.3686
Donor: cadaveric COD other (ref=COD Head trauma)	0.0840	0.2330	0.7185
Donor: living (ref=cadaveric - COD Head trauma)	0.4652	0.1392	0.0008
Ischemia time: linear (ref=average time**)	0.0386	0.0116	0.0009
Ischemia time: missing (ref=average time**)	0.2524	0.0784	0.0013
Ischemia time: quadratic (ref=average time**)	-0.0009	0.0006	0.1610
Previous transplant of this organ type	0.5892	0.0972	<0.0001
Recipient on life support	0.6824	0.0946	<0.0001


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Graft Survival Model Description
1 Year after Transplant
Organ: Liver
Adult (Age 18+)

89.0% alive at 1 Year when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	-0.0239	0.0745	0.7486
ABO compatibility: incompatible (ref=equal)	0.2468	0.2237	0.2700
ABO compatibility: unknown (ref=equal)	-7.0810	81.6186	0.9309
Creatinine > 2	0.3470	0.0646	<0.0001
Diagnosis: AHN*	0.0718	0.0797	0.3680
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.0460	0.0776	0.5528
Diagnosis: Malignant Neoplasms*	0.3543	0.1071	0.0009
Diagnosis: Metabolic Diseases*	-0.0878	0.1441	0.5420
Diagnosis: Other/Missing*	0.0165	0.0962	0.8642
Donor age: 0-17 (ref=35-49)	-0.0674	0.1006	0.5029
Donor age: 18-34 (ref=35-49)	-0.0015	0.0709	0.9832
Donor age: 50-64 (ref=35-49)	0.1604	0.0732	0.0284
Donor age: 65+ (ref=35-49)	0.3844	0.0934	<0.0001
Donor female	0.1355	0.0472	0.0041
Donor race: Asian (ref=White)	0.1871	0.1570	0.2334
Donor race: Black (ref=White)	0.2547	0.0666	0.0001
Donor race: Multi-racial, other, unknown or missing (ref=White)	0.4627	0.2037	0.0231
Ischemia time: linear (ref=average time**)	0.0092	0.0136	0.4987
Ischemia time: missing (ref=average time**)	0.1231	0.1078	0.2534
Ischemia time: quadratic (ref=average time**)	-0.0006	0.0005	0.2327
Previous transplant of this organ type	0.6159	0.0701	<0.0001
Recipient age: 18-34 (ref=35-49)	0.0516	0.1102	0.6398
Recipient age: 50-64 (ref=35-49)	0.0973	0.0555	0.0797
Recipient age: 65+ (ref=35-49)	0.3783	0.0885	<0.0001
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	0.2894	0.0687	<0.0001
Recipient medical condition: in ICU (ref=not hospitalized)	0.3025	0.0676	<0.0001
Recipient on life support	0.3519	0.0806	<0.0001
Recipient race: Asian (ref=White)	0.1134	0.2148	0.5976
Recipient race: Black (ref=White)	0.2154	0.1322	0.1033
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.2948	0.2629	0.2621
Donor age by ischemia time interaction: 0-17 and ischemia time (ref=35-49 and avg ischemia time**)	0.0208	0.0234	0.3736
Donor age by ischemia time interaction: 0-17 and missing ischemia time (ref=35-49 and avg ischemia time**)	-0.1297	0.2222	0.5595
Donor age by ischemia time interaction: 18-34 and ischemia time (ref=35-49 and avg ischemia time**)	0.0216	0.0180	0.2312
Donor age by ischemia time interaction: 18-34 and missing ischemia time (ref=35-49 and avg ischemia time**)	0.0914	0.1439	0.5256
Donor age by ischemia time interaction: 50-64 and ischemia time (ref=35-49 and avg ischemia time**)	0.0123	0.0191	0.5185
Donor age by ischemia time interaction: 50-64 and missing ischemia time (ref=35-49 and avg ischemia time**)	0.1323	0.1555	0.3947
Donor age by ischemia time interaction: 65+ and ischemia time (ref=35-49 and avg ischemia time**)	0.0323	0.0252	0.1992
Donor age by ischemia time interaction: 65+ and missing ischemia time (ref=35-49 and avg ischemia time**)	0.1575	0.2138	0.4615
Recipient age by recipient race interaction: 18-34 and Asian (ref=35-49 and White)	-0.2323	0.6246	0.7099
Recipient age by recipient race interaction: 18-34 and Black (ref=35-49 and White)	-0.1784	0.2487	0.4733
Recipient age by recipient race interaction: 18-34 and multi-racial/other/unknown/missing (ref=35-49 and White)	-0.3375	0.7617	0.6577
Recipient age by recipient race interaction: 50-64 and Asian (ref=35-49 and White)	-0.1985	0.2814	0.4806
Recipient age by recipient race interaction: 50-64 and Black (ref=35-49 and White)	-0.1484	0.1857	0.4242
Recipient age by recipient race interaction: 50-64 and multi-racial/other/unknown/missing (ref=35-49 and White)	0.3911	0.3169	0.2172
Recipient age by recipient race interaction: 65+ and Asian (ref=35-49 and White)	-0.3963	0.4048	0.3277
Recipient age by recipient race interaction: 65+ and Black (ref=35-49 and White)	0.0773	0.3384	0.8194
Recipient age by recipient race interaction: 65+ and multi-racial/other/unknown/missing (ref=35-49 and White)	0.0434	0.5248	0.9341


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Graft Survival Model Description
3 Years after Transplant
Organ: Liver
Adult (Age 18+)

77.4% alive at 3 Years when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	0.0697	0.1342	0.6033
ABO compatibility: incompatible (ref=equal)	-0.0399	0.2944	0.8921
ABO compatibility: unknown (ref=equal)	-10.2667	278.7854	0.9706
Creatinine > 2	0.2460	0.0625	0.0001
Diagnosis: AHN*	0.0069	0.0766	0.9279
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.2325	0.0725	0.0013
Diagnosis: Malignant Neoplasms*	0.1142	0.1180	0.3331
Diagnosis: Metabolic Diseases*	-0.0867	0.1368	0.5264
Diagnosis: Other/Missing*	0.1647	0.0947	0.0819
Donor age: 0-17 (ref=35-49)	-0.1756	0.0798	0.0278
Donor age: 18-34 (ref=35-49)	-0.3328	0.0638	<0.0001
Donor age: 50-64 (ref=35-49)	0.1127	0.0636	0.0766
Donor age: 65+ (ref=35-49)	0.3599	0.0796	<0.0001
Donor female	0.1211	0.0441	0.0061
Donor race: Asian (ref=White)	-0.0302	0.1677	0.8572
Donor race: Black (ref=White)	0.2039	0.0659	0.0020
Donor race: Multi-racial, other, unknown or missing (ref=White)	0.0948	0.2316	0.6825
Ischemia time: linear (ref=average time**)	0.0163	0.0079	0.0390
Ischemia time: missing (ref=average time**)	0.1101	0.0566	0.0519
Ischemia time: quadratic (ref=average time**)	-0.0006	0.0004	0.1546
Previous transplant of this organ type	0.4772	0.0678	<0.0001
Recipient age: 18-34 (ref=35-49)	-0.0256	0.1013	0.8001
Recipient age: 50-64 (ref=35-49)	0.0391	0.0507	0.4407
Recipient age: 65+ (ref=35-49)	0.1957	0.0842	0.0201
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	0.2171	0.0620	0.0005
Recipient medical condition: in ICU (ref=not hospitalized)	0.1599	0.0669	0.0169
Recipient on life support	0.3944	0.0800	<0.0001
Recipient race: Asian (ref=White)	-0.1634	0.2082	0.4327
Recipient race: Black (ref=White)	0.1787	0.1145	0.1186
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.0741	0.2616	0.7769
Donor age by ABO compatibility interaction: 0-17 and compatible (ref=35-49 and equal)	-0.0785	0.2568	0.7597
Donor age by ABO compatibility interaction: 0-17 and incompatible (ref=35-49 and equal)	0.7604	0.5083	0.1347
Donor age by ABO compatibility interaction: 18-34 and compatible (ref=35-49 and equal)	-0.1079	0.1964	0.5826
Donor age by ABO compatibility interaction: 18-34 and incompatible (ref=35-49 and equal)	-0.0399	0.4817	0.9340
Donor age by ABO compatibility interaction: 50-64 and compatible (ref=35-49 and equal)	0.2809	0.1863	0.1317
Donor age by ABO compatibility interaction: 50-64 and incompatible (ref=35-49 and equal)	0.4086	0.4159	0.3259
Donor age by ABO compatibility interaction: 65+ and compatible (ref=35-49 and equal)	-0.0119	0.2442	0.9610
Donor age by ABO compatibility interaction: 65+ and incompatible (ref=35-49 and equal)	-0.5100	0.5410	0.3459
Recipient age by recipient race interaction: 18-34 and Asian (ref=35-49 and White)	-0.4388	0.5504	0.4253
Recipient age by recipient race interaction: 18-34 and Black (ref=35-49 and White)	-0.2365	0.2222	0.2872
Recipient age by recipient race interaction: 18-34 and multi-racial/other/unknown/missing (ref=35-49 and White)	-10.1099	94.2124	0.9145
Recipient age by recipient race interaction: 50-64 and Asian (ref=35-49 and White)	0.2661	0.2560	0.2985
Recipient age by recipient race interaction: 50-64 and Black (ref=35-49 and White)	0.0414	0.1711	0.8086
Recipient age by recipient race interaction: 50-64 and multi-racial/other/unknown/missing (ref=35-49 and White)	0.1008	0.3641	0.7819
Recipient age by recipient race interaction: 65+ and Asian (ref=35-49 and White)	-0.5175	0.5488	0.3457
Recipient age by recipient race interaction: 65+ and Black (ref=35-49 and White)	0.2404	0.3107	0.4391
Recipient age by recipient race interaction: 65+ and multi-racial/other/unknown/missing (ref=35-49 and White)	0.0394	0.5707	0.9450


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Graft Survival Model Description
1 Month after Transplant
Organ: Liver
Pediatric (Age 0-17)

86.5% alive at 1 Month when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	-0.2533	0.4459	0.5699
ABO compatibility: incompatible (ref=equal)	1.5569	0.7842	0.0471
Diagnosis: AHN*	-0.0207	0.2592	0.9364
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.2352	0.4226	0.5778
Diagnosis: Malignant Neoplasms*	-0.9657	0.7235	0.1819
Diagnosis: Metabolic Diseases*	-0.1535	0.3160	0.6272
Diagnosis: Non-Cholestatic Cirrhosis*	-0.5498	0.3735	0.1410
Diagnosis: Other/Missing*	-0.4806	0.2491	0.0537
Donor age: 0-17 (ref=35-49)	-0.6017	0.2718	0.0268
Donor age: 18-34 (ref=35-49)	-0.7342	0.3013	0.0148
Donor age: 50-64 (ref=35-49)	0.9634	0.4029	0.0168
Donor age: 65+ (ref=35-49)	1.8030	1.0837	0.0962
Ischemia time: linear (ref=average time**)	0.0391	0.0332	0.2392
Ischemia time: missing (ref=average time**)	0.1058	0.2631	0.6875
Ischemia time: quadratic (ref=average time**)	-0.0014	0.0016	0.3912
Previous transplant of this organ type	0.4992	0.2081	0.0164
Recipient age: 0-1 (ref=2-10)	0.3058	0.2371	0.1972
Recipient age: 11-17 (ref=2-10)	-0.0772	0.2722	0.7767
Recipient on life support	1.0707	0.2249	<0.0001
Recipient race: Asian (ref=White)	-0.0136	1.0481	0.9896
Recipient race: Black (ref=White)	0.2150	0.3535	0.5431
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.4490	0.7410	0.5446
Donor age by ABO compatibility interaction: 0-17 and compatible (ref=35-49 and equal)	0.1108	0.5614	0.8435
Donor age by ABO compatibility interaction: 0-17 and incompatible (ref=35-49 and equal)	-1.5362	0.9977	0.1236
Donor age by ABO compatibility interaction: 18-34 and compatible (ref=35-49 and equal)	1.1950	0.5518	0.0303
Donor age by ABO compatibility interaction: 18-34 and incompatible (ref=35-49 and equal)	-0.4829	1.0144	0.6340
Donor age by ABO compatibility interaction: 50-64 and compatible (ref=35-49 and equal)	-0.6417	1.1638	0.5814
Donor age by ABO compatibility interaction: 50-64 and incompatible (ref=35-49 and equal)	-15.4943	1095.2349	0.9887
Donor age by ABO compatibility interaction: 65+ and compatible (ref=35-49 and equal)	-14.9073	1085.2113	0.9890
Donor age by ABO compatibility interaction: 65+ and incompatible (ref=35-49 and equal)	12.6520	833.4958	0.9879
Ischemia time by recipient on life support interaction: ischemia time and yes (ref=avg time** and no)	-0.0149	0.0485	0.7594
Ischemia time by recipient on life support interaction: missing ischemia time and yes (ref=avg time** and no)	0.5844	0.3952	0.1392
Recipient age by recipient race interaction: 0-1 and Asian (ref=2-10 and white)	0.2147	1.1327	0.8496
Recipient age by recipient race interaction: 0-1 and Black (ref=2-10 and white)	0.0063	0.4569	0.9890
Recipient age by recipient race interaction: 0-1 and multi-racial/other/unknown/missing (ref=2-10 and white)	-0.7974	1.2638	0.5281
Recipient age by recipient race interaction: 11-17 and Asian (ref=2-10 and White)	-13.6806	833.4948	0.9869
Recipient age by recipient race interaction: 11-17 and Black (ref=2-10 and White)	-0.9057	0.7115	0.2031
Recipient age by recipient race interaction: 11-17 and multi-racial/other/unknown/missing (ref=2-10 and White)	-12.4422	955.5514	0.9896


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Graft Survival Model Description
1 Year after Transplant
Organ: Liver
Pediatric (Age 0-17)

68.9% alive at 1 Year when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	0.2214	0.1636	0.1759
ABO compatibility: incompatible (ref=equal)	0.4533	0.3390	0.1811
Diagnosis: AHN*	0.2312	0.2034	0.2557
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.3094	0.3598	0.3898
Diagnosis: Malignant Neoplasms*	-0.0377	0.3775	0.9205
Diagnosis: Metabolic Diseases*	-0.3132	0.2745	0.2539
Diagnosis: Non-Cholestatic Cirrhosis*	-0.2005	0.2904	0.4899
Diagnosis: Other/Missing*	-0.0944	0.1904	0.6203
Donor age: 0-17 (ref=35-49)	-1.5273	0.5443	0.0050
Donor age: 18-34 (ref=35-49)	-0.6594	0.5302	0.2136
Donor age: 50-64 (ref=35-49)	-0.8687	0.8735	0.3199
Donor age: 65+ (ref=35-49)	28.6306	754.1950	0.9697
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	3.0585	2347.0540	0.9990
Donor: cadaveric COD anoxia (ref=COD Head trauma)	1.2468	1.1815	0.2913
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.0745	0.6064	0.9023
Donor: cadaveric COD other (ref=COD Head trauma)	-13.1350	550.6964	0.9810
Donor: living (ref=cadaveric - COD Head trauma)	-0.1020	0.5590	0.8553
Partial/Split Liver Transplant	0.1985	0.1965	0.3125
Previous transplant of this organ type	0.8399	0.1707	<0.0001
Recipient age: 0-1 (ref=2-10)	-2.0191	0.5457	0.0002
Recipient age: 11-17 (ref=2-10)	-2.7113	0.6876	0.0001
Recipient on life support	0.9135	0.1609	<0.0001
Donor age by donor type interaction: 0-17 and COD CNS tumor (ref=35-49 and COD head trauma)	-15.5092	1020.1567	0.9879
Donor age by donor type interaction: 0-17 and COD anoxia (ref=35-49 and COD head trauma)	-0.7665	1.1898	0.5194
Donor age by donor type interaction: 0-17 and COD cerebrovascular/stroke (ref=35-49 and COD head trauma)	-1.8308	0.7509	0.0148
Donor age by donor type interaction: 0-17 and COD other (ref=35-49 and COD head trauma)	13.6262	550.6966	0.9803
Donor age by donor type interaction: 18-34 and COD anoxia (ref=35-49 and COD head trauma)	-0.5041	1.2942	0.6969
Donor age by donor type interaction: 18-34 and COD cerebrovascular/stroke (ref=35-49 and COD head trauma)	-0.3572	0.6909	0.6051
Donor age by donor type interaction: 18-34 and COD other (ref=35-49 and COD head trauma)	0.9908	1050.4965	0.9992
Donor age by donor type interaction: 18-34 and living donor (ref=35-49 and COD head trauma)	-0.2922	0.5998	0.6261
Donor age by donor type interaction: 50-64 and COD CNS tumor (ref=35-49 and COD head trauma)	-1.6976	2819.2789	0.9995
Donor age by donor type interaction: 50-64 and COD cerebrovascular/stroke (ref=35-49 and COD head trauma)	-0.7188	1.3155	0.5848
Donor age by donor type interaction: 50-64 and COD other (ref=35-49 and COD head trauma)	14.6299	550.6974	0.9788
Donor age by donor type interaction: 50-64 and living donor (ref=35-49 and COD head trauma)	-0.6793	1.4653	0.6430
Donor age by donor type interaction: 65+ and COD cerebrovascular/stroke (ref=35-49 and COD head trauma)	-28.4540	754.1957	0.9699
Recipient age by donor age interaction: 0-1 and 0-17 (ref=2-10 and 35-49)	2.8078	0.5904	<0.0001
Recipient age by donor age interaction: 0-1 and 18-34 (ref=2-10 and 35-49)	1.2973	0.4892	0.0080
Recipient age by donor age interaction: 0-1 and 50-64 (ref=2-10 and 35-49)	3.5031	1.3027	0.0072
Recipient age by donor age interaction: 0-1 and 65+ (ref=2-10 and 35-49)	1.7148	1.5399	0.2655
Recipient age by donor age interaction: 11-17 and 0-17 (ref=2-10 and 35-49)	2.3314	0.7453	0.0018
Recipient age by donor age interaction: 11-17 and 18-34 (ref=2-10 and 35-49)	1.6707	0.6008	0.0054
Recipient age by donor age interaction: 11-17 and 50-64 (ref=2-10 and 35-49)	1.9271	1.1484	0.0933
Recipient age by donor type interaction: 0-1 and COD CNS tumor (ref=2-10 and head trauma)	-1.0920	2347.0538	0.9996
Recipient age by donor type interaction: 0-1 and COD CVA (ref=2-10 and head trauma)	1.6227	0.6096	0.0078
Recipient age by donor type interaction: 0-1 and COD anoxia (ref=2-10 and head trauma)	-0.6011	0.4686	0.1996
Recipient age by donor type interaction: 0-1 and COD other (ref=2-10 and head trauma)	-0.0917	0.7667	0.9048
Recipient age by donor type interaction: 0-1 and living donor (ref=2-10 and cadaveric w/COD head trauma)	0.7617	0.4900	0.1200
Recipient age by donor type interaction: 11-17 and COD CNS tumor (ref=2-10 and head trauma)	-14.4104	3200.6961	0.9964
Recipient age by donor type interaction: 11-17 and COD CVA (ref=2-10 and head trauma)	1.6395	0.6637	0.0135
Recipient age by donor type interaction: 11-17 and COD anoxia (ref=2-10 and head trauma)	0.1333	0.6874	0.8462
Recipient age by donor type interaction: 11-17 and COD other (ref=2-10 and head trauma)	-12.8263	515.3084	0.9801
Recipient age by donor type interaction: 11-17 and living donor (ref=2-10 and cadaveric w/COD head trauma)	2.0889	0.7140	0.0034


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Graft Survival Model Description
3 Years after Transplant
Organ: Liver
Pediatric (Age 0-17)

74.1% alive at 3 Years when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	0.1502	0.1648	0.3621
ABO compatibility: incompatible (ref=equal)	0.2253	0.2301	0.3275
Creatinine > 2	0.3120	0.3206	0.3305
Diagnosis: AHN*	0.0296	0.1838	0.8719
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	0.2733	0.3138	0.3837
Diagnosis: Malignant Neoplasms*	0.5950	0.2625	0.0234
Diagnosis: Metabolic Diseases*	-0.0499	0.2310	0.8290
Diagnosis: Non-Cholestatic Cirrhosis*	0.0849	0.2440	0.7278
Diagnosis: Other/Missing*	0.2130	0.1877	0.2564
Donor age: 0-17 (ref=35-49)	-0.4235	0.2081	0.0418
Donor age: 18-34 (ref=35-49)	-0.1048	0.1976	0.5956
Donor age: 50-64 (ref=35-49)	0.2341	0.3113	0.4519
Donor age: 65+ (ref=35-49)	-1.0637	1.0268	0.3002
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	-12.7250	809.6119	0.9875
Donor: cadaveric COD anoxia (ref=COD Head trauma)	-0.0867	0.3428	0.8003
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.0763	0.2890	0.7919
Donor: cadaveric COD other (ref=COD Head trauma)	-1.2484	1.0128	0.2177
Donor: living (ref=cadaveric - COD Head trauma)	-0.2194	0.3343	0.5116
Previous transplant of this organ type	0.2591	0.1579	0.1008
Recipient age: 0-1 (ref=2-10)	0.2465	0.2042	0.2273
Recipient age: 11-17 (ref=2-10)	-0.3870	0.2489	0.1200
Recipient on life support	0.8795	0.1435	<0.0001
Recipient age by donor type interaction: 0-1 and COD CNS tumor (ref=2-10 and head trauma)	12.9956	809.6126	0.9872
Recipient age by donor type interaction: 0-1 and COD CVA (ref=2-10 and head trauma)	0.1118	0.3926	0.7758
Recipient age by donor type interaction: 0-1 and COD anoxia (ref=2-10 and head trauma)	0.2797	0.4012	0.4857
Recipient age by donor type interaction: 0-1 and COD other (ref=2-10 and head trauma)	1.1178	1.1139	0.3156
Recipient age by donor type interaction: 0-1 and living donor (ref=2-10 and cadaveric w/COD head trauma)	-0.2380	0.3954	0.5472
Recipient age by donor type interaction: 11-17 and COD CVA (ref=2-10 and head trauma)	0.4479	0.4039	0.2675
Recipient age by donor type interaction: 11-17 and COD anoxia (ref=2-10 and head trauma)	0.5212	0.5307	0.3261
Recipient age by donor type interaction: 11-17 and COD other (ref=2-10 and head trauma)	-10.5454	243.7567	0.9655
Recipient age by donor type interaction: 11-17 and living donor (ref=2-10 and cadaveric w/COD head trauma)	-0.3917	1.0799	0.7168


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Patient Survival Model Description
1 Month after First Transplant
Organ: Liver
Adult (Age 18+)

97.0% alive at 1 Month when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Creatinine > 2	0.6692	0.1214	<0.0001
Diagnosis: AHN*	0.3372	0.1476	0.0224
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.1064	0.1621	0.5115
Diagnosis: Malignant Neoplasms*	0.3102	0.2174	0.1537
Diagnosis: Metabolic Diseases*	-0.0080	0.2746	0.9767
Diagnosis: Other/Missing*	0.3602	0.2077	0.0829
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	0.5615	0.3617	0.1205
Donor: cadaveric COD anoxia (ref=COD Head trauma)	0.1599	0.1647	0.3317
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.0247	0.1011	0.8071
Donor: cadaveric COD other (ref=COD Head trauma)	-0.2359	0.3615	0.5140
Donor: living (ref=cadaveric - COD Head trauma)	-0.2498	0.2256	0.2684
Ischemia time: linear (ref=average time**)	0.0452	0.0180	0.0121
Ischemia time: missing (ref=average time**)	0.3751	0.1082	0.0005
Ischemia time: quadratic (ref=average time**)	-0.0034	0.0021	0.1084
Recipient age: 18-34 (ref=35-49)	0.1858	0.1918	0.3328
Recipient age: 50-64 (ref=35-49)	0.2925	0.1051	0.0054
Recipient age: 65+ (ref=35-49)	0.4249	0.1690	0.0119
Recipient on life support	0.8035	0.1328	<0.0001


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Patient Survival Model Description
1 Year after First Transplant
Organ: Liver
Adult (Age 18+)

92.2% alive at 1 Year when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Creatinine > 2	0.5192	0.0797	<0.0001
Diagnosis: AHN*	0.2188	0.0964	0.0232
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.3047	0.1064	0.0042
Diagnosis: Malignant Neoplasms*	0.4893	0.1210	0.0001
Diagnosis: Metabolic Diseases*	-0.1672	0.1809	0.3553
Diagnosis: Other/Missing*	0.2159	0.1388	0.1199
Donor age: 0-17 (ref=35-49)	-0.0883	0.1095	0.4200
Donor age: 18-34 (ref=35-49)	0.0180	0.0750	0.8099
Donor age: 50-64 (ref=35-49)	0.1721	0.0787	0.0287
Donor age: 65+ (ref=35-49)	0.2709	0.1030	0.0086
Ischemia time: linear (ref=average time**)	0.0313	0.0102	0.0021
Ischemia time: missing (ref=average time**)	0.2342	0.0668	0.0005
Ischemia time: quadratic (ref=average time**)	-0.0020	0.0009	0.0279
Recipient age: 18-34 (ref=35-49)	-0.0796	0.1560	0.6097
Recipient age: 50-64 (ref=35-49)	0.2960	0.0699	<0.0001
Recipient age: 65+ (ref=35-49)	0.6130	0.1057	<0.0001
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	0.4268	0.0816	<0.0001
Recipient medical condition: in ICU (ref=not hospitalized)	0.3768	0.0816	<0.0001
Recipient on life support	0.4632	0.1025	<0.0001
Recipient race: Asian (ref=White)	0.0387	0.2948	0.8955
Recipient race: Black (ref=White)	0.3243	0.1636	0.0475
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.4572	0.3823	0.2317
Recipient age by recipient race interaction: 18-34 and Asian (ref=35-49 and White)	-0.6448	1.0528	0.5403
Recipient age by recipient race interaction: 18-34 and Black (ref=35-49 and White)	-0.0283	0.3117	0.9276
Recipient age by recipient race interaction: 18-34 and multi-racial/other/unknown/missing (ref=35-49 and White)	-0.4899	1.0802	0.6501
Recipient age by recipient race interaction: 50-64 and Asian (ref=35-49 and White)	-0.0698	0.3584	0.8456
Recipient age by recipient race interaction: 50-64 and Black (ref=35-49 and White)	-0.1848	0.2212	0.4033
Recipient age by recipient race interaction: 50-64 and multi-racial/other/unknown/missing (ref=35-49 and White)	0.4466	0.4375	0.3074
Recipient age by recipient race interaction: 65+ and Asian (ref=35-49 and White)	-0.2031	0.4690	0.6649
Recipient age by recipient race interaction: 65+ and Black (ref=35-49 and White)	0.2627	0.3543	0.4584
Recipient age by recipient race interaction: 65+ and multi-racial/other/unknown/missing (ref=35-49 and White)	-0.0302	0.6984	0.9655


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Patient Survival Model Description
3 Years after First Transplant
Organ: Liver
Adult (Age 18+)

81.7% alive at 3 Years when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Creatinine > 2	0.3472	0.0760	<0.0001
Diagnosis: AHN*	-0.0406	0.0927	0.6617
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.3573	0.0894	0.0001
Diagnosis: Malignant Neoplasms*	0.3556	0.1222	0.0036
Diagnosis: Metabolic Diseases*	-0.2232	0.1629	0.1706
Diagnosis: Other/Missing*	0.2244	0.1286	0.0809
Donor age: 0-17 (ref=35-49)	-0.2174	0.1428	0.1279
Donor age: 18-34 (ref=35-49)	-0.3498	0.1097	0.0014
Donor age: 50-64 (ref=35-49)	0.2574	0.1078	0.0169
Donor age: 65+ (ref=35-49)	0.0631	0.1639	0.7005
Donor race: Asian (ref=White)	-0.1237	0.1965	0.5288
Donor race: Black (ref=White)	0.1655	0.0790	0.0361
Donor race: Multi-racial, other, unknown or missing (ref=White)	0.1668	0.2608	0.5226
Ischemia time: linear (ref=average time**)	0.0048	0.0094	0.6068
Ischemia time: missing (ref=average time**)	0.1773	0.0636	0.0053
Ischemia time: quadratic (ref=average time**)	-0.0005	0.0005	0.3110
Recipient age: 18-34 (ref=35-49)	-0.0984	0.2298	0.6686
Recipient age: 50-64 (ref=35-49)	0.1108	0.1036	0.2848
Recipient age: 65+ (ref=35-49)	0.1357	0.1853	0.4639
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	0.3374	0.0705	<0.0001
Recipient medical condition: in ICU (ref=not hospitalized)	0.1843	0.0780	0.0182
Recipient on life support	0.5362	0.0994	<0.0001
Recipient race: Asian (ref=White)	-0.2535	0.2625	0.3340
Recipient race: Black (ref=White)	0.2737	0.1351	0.0427
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.3648	0.3369	0.2789
Recipient age by donor age interaction: 18-34 and 0-17 (ref=35-49 and 35-49)	-0.1291	0.3721	0.7286
Recipient age by donor age interaction: 18-34 and 18-34 (ref=35-49 and 35-49)	-0.0280	0.3083	0.9276
Recipient age by donor age interaction: 18-34 and 50-64 (ref=35-49 and 35-49)	-0.7199	0.3804	0.0584
Recipient age by donor age interaction: 18-34 and 65+ (ref=35-49 and 35-49)	0.6279	0.4233	0.1380
Recipient age by donor age interaction: 50-64 and 0-17 (ref=35-49 and 35-49)	0.1183	0.1911	0.5359
Recipient age by donor age interaction: 50-64 and 18-34 (ref=35-49 and 35-49)	0.0823	0.1484	0.5794
Recipient age by donor age interaction: 50-64 and 50-64 (ref=35-49 and 35-49)	-0.1599	0.1492	0.2837
Recipient age by donor age interaction: 50-64 and 65+ (ref=35-49 and 35-49)	0.2611	0.2077	0.2086
Recipient age by donor age interaction: 65+ and 0-17 (ref=35-49 and 35-49)	0.6093	0.3005	0.0426
Recipient age by donor age interaction: 65+ and 18-34 (ref=35-49 and 35-49)	0.2025	0.2635	0.4422
Recipient age by donor age interaction: 65+ and 50-64 (ref=35-49 and 35-49)	0.2495	0.2467	0.3117
Recipient age by donor age interaction: 65+ and 65+ (ref=35-49 and 35-49)	0.4429	0.2896	0.1262
Recipient age by recipient race interaction: 18-34 and Asian (ref=35-49 and White)	-1.0223	1.0458	0.3283
Recipient age by recipient race interaction: 18-34 and Black (ref=35-49 and White)	-0.3777	0.3021	0.2112
Recipient age by recipient race interaction: 18-34 and multi-racial/other/unknown/missing (ref=35-49 and White)	-9.3892	96.0688	0.9221
Recipient age by recipient race interaction: 50-64 and Asian (ref=35-49 and White)	0.3076	0.3117	0.3238
Recipient age by recipient race interaction: 50-64 and Black (ref=35-49 and White)	0.1326	0.1917	0.4892
Recipient age by recipient race interaction: 50-64 and multi-racial/other/unknown/missing (ref=35-49 and White)	0.3500	0.4322	0.4181
Recipient age by recipient race interaction: 65+ and Asian (ref=35-49 and White)	-0.2927	0.5722	0.6091
Recipient age by recipient race interaction: 65+ and Black (ref=35-49 and White)	0.1427	0.3433	0.6775
Recipient age by recipient race interaction: 65+ and multi-racial/other/unknown/missing (ref=35-49 and White)	0.3305	0.6760	0.6249


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Patient Survival Model Description
1 Month after First Transplant
Organ: Liver
Pediatric (Age 0-17)

97.1% alive at 1 Month when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Diagnosis: AHN*	-0.1354	0.3973	0.7331
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.5413	1.0368	0.6016
Diagnosis: Malignant Neoplasms*	-1.0279	1.0293	0.3179
Diagnosis: Metabolic Diseases*	-1.3460	0.6519	0.0390
Diagnosis: Non-Cholestatic Cirrhosis*	-0.8984	0.6174	0.1456
Diagnosis: Other/Missing*	-0.6048	0.4163	0.1463
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	0.7475	1.0499	0.4765
Donor: cadaveric COD anoxia (ref=COD Head trauma)	-0.5572	0.4980	0.2631
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.7873	0.3487	0.0240
Donor: cadaveric COD other (ref=COD Head trauma)	0.1048	0.7439	0.8880
Donor: living (ref=cadaveric - COD Head trauma)	0.1172	0.4441	0.7919
Ischemia time: linear (ref=average time**)	0.1028	0.0615	0.0944
Ischemia time: missing (ref=average time**)	-0.2363	0.5778	0.6826
Ischemia time: quadratic (ref=average time**)	-0.0005	0.0022	0.8349
Partial/Split Liver Transplant	0.1808	0.3266	0.5799
Recipient age: 0-1 (ref=2-10)	0.5783	0.4033	0.1516
Recipient age: 11-17 (ref=2-10)	0.1569	0.4590	0.7324
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	-0.4786	0.6534	0.4639
Recipient medical condition: in ICU (ref=not hospitalized)	0.0604	0.4489	0.8930
Recipient on life support	2.0279	0.4022	<0.0001
Recipient race: Asian (ref=White)	-12.9963	1403.5198	0.9926
Recipient race: Black (ref=White)	0.6689	0.6026	0.2670
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-14.0296	1233.6210	0.9909
Ischemia time by recipient medical condition interaction: ischemia time and hospitalized not in ICU (ref=avg time** and not hospitalized)	-0.2051	0.1397	0.1421
Ischemia time by recipient medical condition interaction: ischemia time and in ICU (ref=avg time** and not hospitalized)	-0.0627	0.0726	0.3875
Ischemia time by recipient medical condition interaction: missing ischemia time and hospitalized not in ICU (ref=avg time** and not hospitalized)	-17.6056	11325.7436	0.9988
Ischemia time by recipient medical condition interaction: missing ischemia time and in ICU (ref=avg time** and not hospitalized)	0.8481	0.6812	0.2131
Recipient age by recipient race interaction: 0-1 and Asian (ref=2-10 and white)	13.8169	1403.5199	0.9921
Recipient age by recipient race interaction: 0-1 and Black (ref=2-10 and white)	-0.5868	0.7228	0.4168
Recipient age by recipient race interaction: 0-1 and multi-racial/other/unknown/missing (ref=2-10 and white)	-1.0405	1593.1083	0.9995
Recipient age by recipient race interaction: 11-17 and Asian (ref=2-10 and White)	-3.3880	4691.5611	0.9994
Recipient age by recipient race interaction: 11-17 and Black (ref=2-10 and White)	-1.7250	1.2101	0.1540
Recipient age by recipient race interaction: 11-17 and multi-racial/other/unknown/missing (ref=2-10 and White)	-1.8273	4468.5474	0.9997


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Patient Survival Model Description
1 Year after First Transplant
Organ: Liver
Pediatric (Age 0-17)

93.0% alive at 1 Year when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	0.1416	0.2237	0.5267
ABO compatibility: incompatible (ref=equal)	0.1819	0.4377	0.6777
Diagnosis: AHN*	0.1070	0.2671	0.6888
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.8991	0.7229	0.2135
Diagnosis: Malignant Neoplasms*	0.1643	0.4074	0.6867
Diagnosis: Metabolic Diseases*	-0.6718	0.3898	0.0848
Diagnosis: Non-Cholestatic Cirrhosis*	-0.9367	0.4418	0.0340
Diagnosis: Other/Missing*	-0.2791	0.2806	0.3198
Donor Hispanic/Latino	-0.2484	0.2689	0.3555
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	0.3710	1.0230	0.7168
Donor: cadaveric COD anoxia (ref=COD Head trauma)	-0.0162	0.3302	0.9608
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.5344	0.2704	0.0481
Donor: cadaveric COD other (ref=COD Head trauma)	0.3216	0.4397	0.4645
Donor: living (ref=cadaveric - COD Head trauma)	0.3097	0.2590	0.2318
Partial/Split Liver Transplant	0.4104	0.2323	0.0773
Recipient on life support	1.4280	0.2250	<0.0001


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Patient Survival Model Description
3 Years after First Transplant
Organ: Liver
Pediatric (Age 0-17)

90.7% alive at 3 Years when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Creatinine > 2	0.0563	0.5451	0.9178
Diagnosis: AHN*	0.3904	0.2369	0.0994
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	0.3100	0.4908	0.5276
Diagnosis: Malignant Neoplasms*	0.9612	0.3137	0.0022
Diagnosis: Metabolic Diseases*	0.0800	0.2932	0.7849
Diagnosis: Non-Cholestatic Cirrhosis*	0.4042	0.3405	0.2352
Diagnosis: Other/Missing*	0.5745	0.2641	0.0296
Donor age: 0-17 (ref=35-49)	0.0500	0.3606	0.8896
Donor age: 18-34 (ref=35-49)	-0.0146	0.3925	0.9704
Donor age: 50-64 (ref=35-49)	0.6633	0.5529	0.2302
Donor age: 65+ (ref=35-49)	-12.2330	409.5521	0.9762
Ischemia time: linear (ref=average time**)	-0.0028	0.0774	0.9716
Ischemia time: missing (ref=average time**)	0.0698	0.6056	0.9083
Ischemia time: quadratic (ref=average time**)	-0.0001	0.0023	0.9763
Recipient age: 0-1 (ref=2-10)	0.4842	0.1965	0.0137
Recipient age: 11-17 (ref=2-10)	-0.3118	0.2669	0.2428
Recipient on life support	1.1193	0.1902	<0.0001
Donor age by ischemia time interaction: 0-17 and ischemia time (ref=35-49 and avg ischemia time**)	-0.0016	0.0857	0.9849
Donor age by ischemia time interaction: 0-17 and missing ischemia time (ref=35-49 and avg ischemia time**)	-0.3313	0.6808	0.6266
Donor age by ischemia time interaction: 18-34 and ischemia time (ref=35-49 and avg ischemia time**)	0.0153	0.0875	0.8613
Donor age by ischemia time interaction: 18-34 and missing ischemia time (ref=35-49 and avg ischemia time**)	0.8720	0.6878	0.2049
Donor age by ischemia time interaction: 50-64 and ischemia time (ref=35-49 and avg ischemia time**)	0.1090	0.1431	0.4462
Donor age by ischemia time interaction: 50-64 and missing ischemia time (ref=35-49 and avg ischemia time**)	0.7862	0.9516	0.4087
Donor age by ischemia time interaction: 65+ and ischemia time (ref=35-49 and avg ischemia time**)	-0.0011	80.5870	1.0000
Donor age by ischemia time interaction: 65+ and missing ischemia time (ref=35-49 and avg ischemia time**)	-0.9014	1174.1421	0.9994


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

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