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Research Resources: Analytic Conventions - Model Description (Liver - Deceased)

Model Descriptions on This Page

Graft Survival Model Description

Adult (Age 18+)

Pediatric (Age 0-17)

Patient Survival Model Description

Adult (Age 18+)

Pediatric (Age 0-17)

Deceased Donor Graft Survival Model Description
1 Month after Transplant
Organ: Liver
Adult (Age 18+)

94.8% alive at 1 Month when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	0.0305	0.1097	0.7807
ABO compatibility: incompatible (ref=equal)	0.4019	0.2846	0.1579
ABO compatibility: unknown (ref=equal)	-6.3986	128.2332	0.9602
Creatinine > 2	0.3545	0.0910	0.0001
Diagnosis: AHN*	0.1333	0.1101	0.2262
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.0213	0.1178	0.8563
Diagnosis: Malignant Neoplasms*	0.3508	0.1629	0.0313
Diagnosis: Metabolic Diseases*	0.1274	0.1942	0.5117
Diagnosis: Other/Missing*	0.0935	0.1345	0.4869
Donor age: 0-17 (ref=35-49)	0.0115	0.1321	0.9306
Donor age: 18-34 (ref=35-49)	-0.0106	0.1013	0.9166
Donor age: 50-64 (ref=35-49)	0.1300	0.0968	0.1791
Donor age: 65+ (ref=35-49)	0.3143	0.1240	0.0112
Donor female	0.1630	0.0719	0.0234
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	0.3344	0.2960	0.2586
Donor: cadaveric COD anoxia (ref=COD Head trauma)	0.1531	0.1299	0.2388
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.0795	0.0931	0.3932
Donor: cadaveric COD other (ref=COD Head trauma)	0.0937	0.2333	0.6880
Ischemia time: linear (ref=average time**)	0.0565	0.0131	<0.0001
Ischemia time: missing (ref=average time**)	0.3386	0.0808	<0.0001
Ischemia time: quadratic (ref=average time**)	-0.0015	0.0007	0.0442
Previous transplant of this organ type	0.5823	0.0986	<0.0001
Recipient on life support	0.6883	0.0961	<0.0001


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Graft Survival Model Description
1 Year after Transplant
Organ: Liver
Adult (Age 18+)

89.2% alive at 1 Year when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	-0.0541	0.0799	0.4989
ABO compatibility: incompatible (ref=equal)	0.2918	0.2250	0.1947
ABO compatibility: unknown (ref=equal)	-6.6724	82.3932	0.9355
Creatinine > 2	0.3610	0.0657	<0.0001
Diagnosis: AHN*	0.0671	0.0818	0.4121
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.1070	0.0848	0.2071
Diagnosis: Malignant Neoplasms*	0.3908	0.1119	0.0005
Diagnosis: Metabolic Diseases*	-0.1457	0.1533	0.3416
Diagnosis: Other/Missing*	0.0101	0.0988	0.9182
Donor age: 0-17 (ref=35-49)	-0.0240	0.1023	0.8147
Donor age: 18-34 (ref=35-49)	0.0034	0.0746	0.9634
Donor age: 50-64 (ref=35-49)	0.1792	0.0762	0.0187
Donor age: 65+ (ref=35-49)	0.4261	0.0951	<0.0001
Donor female	0.1198	0.0494	0.0152
Donor race: Asian (ref=White)	0.1977	0.1642	0.2285
Donor race: Black (ref=White)	0.2728	0.0679	0.0001
Donor race: Multi-racial, other, unknown or missing (ref=White)	0.3468	0.2522	0.1691
Ischemia time: linear (ref=average time**)	0.0358	0.0159	0.0247
Ischemia time: missing (ref=average time**)	0.1136	0.1221	0.3523
Ischemia time: quadratic (ref=average time**)	-0.0015	0.0006	0.0137
Previous transplant of this organ type	0.6356	0.0713	<0.0001
Recipient age: 18-34 (ref=35-49)	0.0153	0.1185	0.8971
Recipient age: 50-64 (ref=35-49)	0.0915	0.0579	0.1140
Recipient age: 65+ (ref=35-49)	0.4219	0.0908	<0.0001
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	0.2694	0.0730	0.0002
Recipient medical condition: in ICU (ref=not hospitalized)	0.3106	0.0693	<0.0001
Recipient on life support	0.3434	0.0820	<0.0001
Recipient race: Asian (ref=White)	0.1843	0.2194	0.4009
Recipient race: Black (ref=White)	0.1818	0.1386	0.1896
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.2977	0.2821	0.2913
Donor age by ischemia time interaction: 0-17 and ischemia time (ref=35-49 and avg ischemia time**)	0.0101	0.0259	0.6973
Donor age by ischemia time interaction: 0-17 and missing ischemia time (ref=35-49 and avg ischemia time**)	-0.1287	0.2297	0.5752
Donor age by ischemia time interaction: 18-34 and ischemia time (ref=35-49 and avg ischemia time**)	0.0148	0.0209	0.4795
Donor age by ischemia time interaction: 18-34 and missing ischemia time (ref=35-49 and avg ischemia time**)	0.1092	0.1602	0.4956
Donor age by ischemia time interaction: 50-64 and ischemia time (ref=35-49 and avg ischemia time**)	0.0082	0.0211	0.6962
Donor age by ischemia time interaction: 50-64 and missing ischemia time (ref=35-49 and avg ischemia time**)	0.1290	0.1691	0.4456
Donor age by ischemia time interaction: 65+ and ischemia time (ref=35-49 and avg ischemia time**)	0.0130	0.0267	0.6269
Donor age by ischemia time interaction: 65+ and missing ischemia time (ref=35-49 and avg ischemia time**)	0.1567	0.2215	0.4793
Recipient age by recipient race interaction: 18-34 and Asian (ref=35-49 and White)	-0.1903	0.6279	0.7619
Recipient age by recipient race interaction: 18-34 and Black (ref=35-49 and White)	-0.1340	0.2605	0.6070
Recipient age by recipient race interaction: 18-34 and multi-racial/other/unknown/missing (ref=35-49 and White)	-0.8366	1.0454	0.4235
Recipient age by recipient race interaction: 50-64 and Asian (ref=35-49 and White)	-0.2285	0.2893	0.4296
Recipient age by recipient race interaction: 50-64 and Black (ref=35-49 and White)	-0.1210	0.1927	0.5302
Recipient age by recipient race interaction: 50-64 and multi-racial/other/unknown/missing (ref=35-49 and White)	0.4013	0.3457	0.2457
Recipient age by recipient race interaction: 65+ and Asian (ref=35-49 and White)	-0.5311	0.4247	0.2111
Recipient age by recipient race interaction: 65+ and Black (ref=35-49 and White)	0.0867	0.3414	0.7995
Recipient age by recipient race interaction: 65+ and multi-racial/other/unknown/missing (ref=35-49 and White)	-0.2647	0.6483	0.6830


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Graft Survival Model Description
3 Years after Transplant
Organ: Liver
Adult (Age 18+)

77.7% alive at 3 Years when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	0.0846	0.1365	0.5352
ABO compatibility: incompatible (ref=equal)	-0.0138	0.2946	0.9627
ABO compatibility: unknown (ref=equal)	-10.2815	280.9707	0.9708
Creatinine > 2	0.2529	0.0630	0.0001
Diagnosis: AHN*	0.0027	0.0776	0.9719
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.2242	0.0734	0.0022
Diagnosis: Malignant Neoplasms*	0.0584	0.1242	0.6384
Diagnosis: Metabolic Diseases*	-0.0594	0.1370	0.6648
Diagnosis: Other/Missing*	0.1688	0.0958	0.0781
Donor age: 0-17 (ref=35-49)	-0.1506	0.0805	0.0614
Donor age: 18-34 (ref=35-49)	-0.3270	0.0653	<0.0001
Donor age: 50-64 (ref=35-49)	0.1295	0.0647	0.0454
Donor age: 65+ (ref=35-49)	0.3891	0.0802	<0.0001
Donor female	0.1169	0.0448	0.0090
Donor race: Asian (ref=White)	-0.0546	0.1723	0.7513
Donor race: Black (ref=White)	0.2010	0.0667	0.0026
Donor race: Multi-racial, other, unknown or missing (ref=White)	0.0266	0.2521	0.9160
Ischemia time: linear (ref=average time**)	0.0276	0.0083	0.0009
Ischemia time: missing (ref=average time**)	0.1093	0.0577	0.0581
Ischemia time: quadratic (ref=average time**)	-0.0010	0.0005	0.0292
Previous transplant of this organ type	0.4924	0.0683	<0.0001
Recipient age: 18-34 (ref=35-49)	-0.0098	0.1022	0.9236
Recipient age: 50-64 (ref=35-49)	0.0225	0.0514	0.6613
Recipient age: 65+ (ref=35-49)	0.1909	0.0850	0.0247
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	0.2156	0.0629	0.0006
Recipient medical condition: in ICU (ref=not hospitalized)	0.1650	0.0675	0.0145
Recipient on life support	0.3826	0.0807	<0.0001
Recipient race: Asian (ref=White)	-0.1582	0.2083	0.4476
Recipient race: Black (ref=White)	0.1511	0.1158	0.1919
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.1776	0.2805	0.5268
Donor age by ABO compatibility interaction: 0-17 and compatible (ref=35-49 and equal)	-0.0785	0.2580	0.7608
Donor age by ABO compatibility interaction: 0-17 and incompatible (ref=35-49 and equal)	0.7441	0.5085	0.1434
Donor age by ABO compatibility interaction: 18-34 and compatible (ref=35-49 and equal)	-0.0895	0.1991	0.6530
Donor age by ABO compatibility interaction: 18-34 and incompatible (ref=35-49 and equal)	-0.0410	0.4819	0.9322
Donor age by ABO compatibility interaction: 50-64 and compatible (ref=35-49 and equal)	0.2838	0.1881	0.1314
Donor age by ABO compatibility interaction: 50-64 and incompatible (ref=35-49 and equal)	0.4049	0.4162	0.3307
Donor age by ABO compatibility interaction: 65+ and compatible (ref=35-49 and equal)	-0.0221	0.2454	0.9284
Donor age by ABO compatibility interaction: 65+ and incompatible (ref=35-49 and equal)	-0.5748	0.5414	0.2884
Recipient age by recipient race interaction: 18-34 and Asian (ref=35-49 and White)	-0.4631	0.5505	0.4003
Recipient age by recipient race interaction: 18-34 and Black (ref=35-49 and White)	-0.3006	0.2288	0.1890
Recipient age by recipient race interaction: 18-34 and multi-racial/other/unknown/missing (ref=35-49 and White)	-10.0458	94.3157	0.9152
Recipient age by recipient race interaction: 50-64 and Asian (ref=35-49 and White)	0.2312	0.2588	0.3717
Recipient age by recipient race interaction: 50-64 and Black (ref=35-49 and White)	0.0955	0.1721	0.5790
Recipient age by recipient race interaction: 50-64 and multi-racial/other/unknown/missing (ref=35-49 and White)	0.1676	0.3834	0.6621
Recipient age by recipient race interaction: 65+ and Asian (ref=35-49 and White)	-0.4815	0.5490	0.3805
Recipient age by recipient race interaction: 65+ and Black (ref=35-49 and White)	0.2201	0.3215	0.4937
Recipient age by recipient race interaction: 65+ and multi-racial/other/unknown/missing (ref=35-49 and White)	0.1434	0.5797	0.8047


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Graft Survival Model Description
1 Month after Transplant
Organ: Liver
Pediatric (Age 0-17)

89.0% alive at 1 Month when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	-0.5650	0.6561	0.3892
ABO compatibility: incompatible (ref=equal)	1.9288	0.8332	0.0206
Donor age: 0-17 (ref=35-49)	-0.6845	0.3319	0.0392
Donor age: 18-34 (ref=35-49)	-0.5165	0.3858	0.1807
Donor age: 50-64 (ref=35-49)	1.0752	0.4620	0.0200
Donor age: 65+ (ref=35-49)	2.0816	1.1125	0.0613
Ischemia time: linear (ref=average time**)	0.0626	0.0428	0.1432
Ischemia time: missing (ref=average time**)	0.0479	0.3217	0.8816
Ischemia time: quadratic (ref=average time**)	-0.0029	0.0028	0.2919
Previous transplant of this organ type	0.5363	0.2210	0.0152
Recipient age: 0-1 (ref=2-10)	0.5592	0.2601	0.0316
Recipient age: 11-17 (ref=2-10)	-0.1772	0.3027	0.5584
Recipient on life support	0.9627	0.2342	<0.0001
Recipient race: Asian (ref=White)	0.4946	1.0641	0.6421
Recipient race: Black (ref=White)	0.1839	0.3838	0.6319
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.1048	0.7662	0.8912
Donor age by ABO compatibility interaction: 0-17 and compatible (ref=35-49 and equal)	0.3494	0.7439	0.6386
Donor age by ABO compatibility interaction: 0-17 and incompatible (ref=35-49 and equal)	-1.9903	1.0435	0.0565
Donor age by ABO compatibility interaction: 18-34 and compatible (ref=35-49 and equal)	0.8629	0.7776	0.2671
Donor age by ABO compatibility interaction: 18-34 and incompatible (ref=35-49 and equal)	-1.5083	1.1166	0.1768
Donor age by ABO compatibility interaction: 50-64 and compatible (ref=35-49 and equal)	-0.5120	1.2633	0.6853
Donor age by ABO compatibility interaction: 50-64 and incompatible (ref=35-49 and equal)	-16.0653	1237.8262	0.9896
Donor age by ABO compatibility interaction: 65+ and compatible (ref=35-49 and equal)	-15.6304	1105.3194	0.9887
Donor age by ABO compatibility interaction: 65+ and incompatible (ref=35-49 and equal)	12.1732	901.6890	0.9892
Ischemia time by recipient on life support interaction: ischemia time and yes (ref=avg time** and no)	0.0457	0.0615	0.4573
Ischemia time by recipient on life support interaction: missing ischemia time and yes (ref=avg time** and no)	0.8010	0.4654	0.0852
Recipient age by recipient race interaction: 0-1 and Asian (ref=2-10 and white)	0.0937	1.1472	0.9349
Recipient age by recipient race interaction: 0-1 and Black (ref=2-10 and white)	-0.0254	0.5011	0.9595
Recipient age by recipient race interaction: 0-1 and multi-racial/other/unknown/missing (ref=2-10 and white)	0.0083	1.2750	0.9948
Recipient age by recipient race interaction: 11-17 and Asian (ref=2-10 and White)	-14.1798	901.6881	0.9875
Recipient age by recipient race interaction: 11-17 and Black (ref=2-10 and White)	-1.2455	0.8447	0.1403
Recipient age by recipient race interaction: 11-17 and multi-racial/other/unknown/missing (ref=2-10 and White)	-12.7922	1062.0056	0.9904


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Graft Survival Model Description
1 Year after Transplant
Organ: Liver
Pediatric (Age 0-17)

71.5% alive at 1 Year when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	-0.0437	0.1868	0.8149
ABO compatibility: incompatible (ref=equal)	0.4445	0.3548	0.2102
Donor age: 0-17 (ref=35-49)	-1.4519	0.5463	0.0079
Donor age: 18-34 (ref=35-49)	-0.4979	0.5434	0.3596
Donor age: 50-64 (ref=35-49)	-0.5655	0.8736	0.5175
Donor age: 65+ (ref=35-49)	28.9438	888.2036	0.9740
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	2.9640	2367.8663	0.9990
Donor: cadaveric COD anoxia (ref=COD Head trauma)	0.9365	1.2214	0.4433
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.0307	0.6022	0.9593
Donor: cadaveric COD other (ref=COD Head trauma)	-13.1093	691.1595	0.9849
Partial/Split Liver Transplant	0.2103	0.1944	0.2791
Previous transplant of this organ type	0.9264	0.1752	<0.0001
Recipient age: 0-1 (ref=2-10)	-1.5838	0.6954	0.0228
Recipient age: 11-17 (ref=2-10)	-2.3829	0.8069	0.0031
Recipient on life support	0.8168	0.1726	<0.0001
Donor age by donor type interaction: 0-17 and COD CNS tumor (ref=35-49 and COD head trauma)	-15.7078	1025.7206	0.9878
Donor age by donor type interaction: 0-17 and COD anoxia (ref=35-49 and COD head trauma)	-0.5101	1.2209	0.6761
Donor age by donor type interaction: 0-17 and COD cerebrovascular/stroke (ref=35-49 and COD head trauma)	-1.5214	0.7607	0.0455
Donor age by donor type interaction: 0-17 and COD other (ref=35-49 and COD head trauma)	13.6533	691.1596	0.9842
Donor age by donor type interaction: 18-34 and COD anoxia (ref=35-49 and COD head trauma)	-0.2950	1.3266	0.8240
Donor age by donor type interaction: 18-34 and COD cerebrovascular/stroke (ref=35-49 and COD head trauma)	-0.0014	0.7148	0.9984
Donor age by donor type interaction: 18-34 and COD other (ref=35-49 and COD head trauma)	0.9215	1155.2776	0.9994
Donor age by donor type interaction: 50-64 and COD CNS tumor (ref=35-49 and COD head trauma)	-1.6102	2837.7181	0.9995
Donor age by donor type interaction: 50-64 and COD cerebrovascular/stroke (ref=35-49 and COD head trauma)	-0.6663	1.2841	0.6039
Donor age by donor type interaction: 50-64 and COD other (ref=35-49 and COD head trauma)	14.3514	691.1603	0.9834
Donor age by donor type interaction: 65+ and COD cerebrovascular/stroke (ref=35-49 and COD head trauma)	-28.8134	888.2041	0.9741
Recipient age by donor age interaction: 0-1 and 0-17 (ref=2-10 and 35-49)	2.4318	0.7233	0.0008
Recipient age by donor age interaction: 0-1 and 18-34 (ref=2-10 and 35-49)	0.8219	0.7261	0.2576
Recipient age by donor age interaction: 0-1 and 50-64 (ref=2-10 and 35-49)	2.7699	1.4170	0.0506
Recipient age by donor age interaction: 0-1 and 65+ (ref=2-10 and 35-49)	1.9337	1.5241	0.2045
Recipient age by donor age interaction: 11-17 and 0-17 (ref=2-10 and 35-49)	1.9683	0.8422	0.0194
Recipient age by donor age interaction: 11-17 and 18-34 (ref=2-10 and 35-49)	1.2655	0.7773	0.1035
Recipient age by donor age interaction: 11-17 and 50-64 (ref=2-10 and 35-49)	1.6244	1.1461	0.1564
Recipient age by donor type interaction: 0-1 and COD CNS tumor (ref=2-10 and head trauma)	-0.9869	2367.8661	0.9997
Recipient age by donor type interaction: 0-1 and COD CVA (ref=2-10 and head trauma)	1.4271	0.6432	0.0265
Recipient age by donor type interaction: 0-1 and COD anoxia (ref=2-10 and head trauma)	-0.5434	0.4695	0.2471
Recipient age by donor type interaction: 0-1 and COD other (ref=2-10 and head trauma)	-0.1418	0.7646	0.8528
Recipient age by donor type interaction: 11-17 and COD CNS tumor (ref=2-10 and head trauma)	-14.7476	3223.4531	0.9963
Recipient age by donor type interaction: 11-17 and COD CVA (ref=2-10 and head trauma)	1.4738	0.6944	0.0338
Recipient age by donor type interaction: 11-17 and COD anoxia (ref=2-10 and head trauma)	0.1934	0.6899	0.7792
Recipient age by donor type interaction: 11-17 and COD other (ref=2-10 and head trauma)	-12.8077	557.8559	0.9817


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Graft Survival Model Description
3 Years after Transplant
Organ: Liver
Pediatric (Age 0-17)

75.0% alive at 3 Years when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	0.0967	0.1785	0.5878
ABO compatibility: incompatible (ref=equal)	0.1613	0.2423	0.5057
Creatinine > 2	0.2610	0.3331	0.4333
Diagnosis: AHN*	0.0618	0.1983	0.7552
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	0.2972	0.3301	0.3679
Diagnosis: Malignant Neoplasms*	0.6307	0.2845	0.0266
Diagnosis: Metabolic Diseases*	-0.0871	0.2522	0.7299
Diagnosis: Non-Cholestatic Cirrhosis*	0.0684	0.2562	0.7894
Diagnosis: Other/Missing*	0.2772	0.2041	0.1743
Donor age: 0-17 (ref=35-49)	-0.3900	0.2318	0.0925
Donor age: 18-34 (ref=35-49)	-0.0490	0.2402	0.8385
Donor age: 50-64 (ref=35-49)	0.1863	0.3285	0.5706
Donor age: 65+ (ref=35-49)	-1.0930	1.0294	0.2883
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	-13.6821	1318.2137	0.9917
Donor: cadaveric COD anoxia (ref=COD Head trauma)	-0.0827	0.3431	0.8094
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.1058	0.2904	0.7155
Donor: cadaveric COD other (ref=COD Head trauma)	-1.2419	1.0129	0.2202
Previous transplant of this organ type	0.2471	0.1660	0.1366
Recipient age: 0-1 (ref=2-10)	0.2499	0.2050	0.2228
Recipient age: 11-17 (ref=2-10)	-0.3889	0.2498	0.1195
Recipient on life support	0.8876	0.1522	<0.0001
Recipient age by donor type interaction: 0-1 and COD CNS tumor (ref=2-10 and head trauma)	13.9369	1318.2141	0.9916
Recipient age by donor type interaction: 0-1 and COD CVA (ref=2-10 and head trauma)	0.1099	0.3927	0.7796
Recipient age by donor type interaction: 0-1 and COD anoxia (ref=2-10 and head trauma)	0.2827	0.4017	0.4816
Recipient age by donor type interaction: 0-1 and COD other (ref=2-10 and head trauma)	1.1068	1.1140	0.3204
Recipient age by donor type interaction: 11-17 and COD CVA (ref=2-10 and head trauma)	0.4606	0.4045	0.2548
Recipient age by donor type interaction: 11-17 and COD anoxia (ref=2-10 and head trauma)	0.5342	0.5321	0.3154
Recipient age by donor type interaction: 11-17 and COD other (ref=2-10 and head trauma)	-11.5071	397.7551	0.9769


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Patient Survival Model Description
1 Month after First Transplant
Organ: Liver
Adult (Age 18+)

97.0% alive at 1 Month when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Creatinine > 2	0.6771	0.1223	<0.0001
Diagnosis: AHN*	0.2423	0.1534	0.1142
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.0800	0.1673	0.6327
Diagnosis: Malignant Neoplasms*	0.3008	0.2270	0.1851
Diagnosis: Metabolic Diseases*	0.0056	0.2749	0.9837
Diagnosis: Other/Missing*	0.2570	0.2200	0.2427
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	0.5663	0.3617	0.1174
Donor: cadaveric COD anoxia (ref=COD Head trauma)	0.1602	0.1647	0.3309
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.0246	0.1011	0.8075
Donor: cadaveric COD other (ref=COD Head trauma)	-0.2299	0.3615	0.5248
Ischemia time: linear (ref=average time**)	0.0646	0.0204	0.0016
Ischemia time: missing (ref=average time**)	0.4212	0.1099	0.0001
Ischemia time: quadratic (ref=average time**)	-0.0051	0.0028	0.0717
Recipient age: 18-34 (ref=35-49)	0.2034	0.1969	0.3015
Recipient age: 50-64 (ref=35-49)	0.2484	0.1074	0.0207
Recipient age: 65+ (ref=35-49)	0.4156	0.1724	0.0159
Recipient on life support	0.8023	0.1345	<0.0001


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Patient Survival Model Description
1 Year after First Transplant
Organ: Liver
Adult (Age 18+)

92.2% alive at 1 Year when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Creatinine > 2	0.5121	0.0813	<0.0001
Diagnosis: AHN*	0.2063	0.0991	0.0373
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.2611	0.1120	0.0198
Diagnosis: Malignant Neoplasms*	0.5158	0.1269	<0.0001
Diagnosis: Metabolic Diseases*	-0.2158	0.1900	0.2560
Diagnosis: Other/Missing*	0.2172	0.1439	0.1313
Donor age: 0-17 (ref=35-49)	-0.0842	0.1114	0.4496
Donor age: 18-34 (ref=35-49)	0.0080	0.0796	0.9200
Donor age: 50-64 (ref=35-49)	0.1639	0.0820	0.0456
Donor age: 65+ (ref=35-49)	0.2737	0.1048	0.0090
Ischemia time: linear (ref=average time**)	0.0449	0.0122	0.0002
Ischemia time: missing (ref=average time**)	0.2447	0.0714	0.0006
Ischemia time: quadratic (ref=average time**)	-0.0039	0.0016	0.0130
Recipient age: 18-34 (ref=35-49)	-0.0497	0.1627	0.7598
Recipient age: 50-64 (ref=35-49)	0.2857	0.0724	0.0001
Recipient age: 65+ (ref=35-49)	0.6249	0.1089	<0.0001
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	0.4283	0.0859	<0.0001
Recipient medical condition: in ICU (ref=not hospitalized)	0.3977	0.0828	<0.0001
Recipient on life support	0.4321	0.1041	<0.0001
Recipient race: Asian (ref=White)	0.0528	0.3078	0.8637
Recipient race: Black (ref=White)	0.2649	0.1714	0.1222
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.4821	0.4126	0.2426
Recipient age by recipient race interaction: 18-34 and Asian (ref=35-49 and White)	-0.6456	1.0574	0.5415
Recipient age by recipient race interaction: 18-34 and Black (ref=35-49 and White)	-0.0787	0.3273	0.8099
Recipient age by recipient race interaction: 18-34 and multi-racial/other/unknown/missing (ref=35-49 and White)	-0.4027	1.0922	0.7123
Recipient age by recipient race interaction: 50-64 and Asian (ref=35-49 and White)	-0.1239	0.3766	0.7422
Recipient age by recipient race interaction: 50-64 and Black (ref=35-49 and White)	-0.1610	0.2303	0.4846
Recipient age by recipient race interaction: 50-64 and multi-racial/other/unknown/missing (ref=35-49 and White)	0.5210	0.4742	0.2720
Recipient age by recipient race interaction: 65+ and Asian (ref=35-49 and White)	-0.0989	0.4778	0.8360
Recipient age by recipient race interaction: 65+ and Black (ref=35-49 and White)	0.2936	0.3587	0.4130
Recipient age by recipient race interaction: 65+ and multi-racial/other/unknown/missing (ref=35-49 and White)	-0.2188	0.8243	0.7907


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Patient Survival Model Description
3 Years after First Transplant
Organ: Liver
Adult (Age 18+)

81.6% alive at 3 Years when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Creatinine > 2	0.3503	0.0767	<0.0001
Diagnosis: AHN*	-0.0554	0.0942	0.5567
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.3433	0.0904	0.0001
Diagnosis: Malignant Neoplasms*	0.2932	0.1300	0.0241
Diagnosis: Metabolic Diseases*	-0.1919	0.1631	0.2393
Diagnosis: Other/Missing*	0.2309	0.1305	0.0769
Donor age: 0-17 (ref=35-49)	-0.2219	0.1435	0.1221
Donor age: 18-34 (ref=35-49)	-0.3688	0.1115	0.0009
Donor age: 50-64 (ref=35-49)	0.2477	0.1090	0.0230
Donor age: 65+ (ref=35-49)	0.0613	0.1645	0.7093
Donor race: Asian (ref=White)	-0.1692	0.2039	0.4067
Donor race: Black (ref=White)	0.1736	0.0797	0.0294
Donor race: Multi-racial, other, unknown or missing (ref=White)	0.1443	0.2798	0.6059
Ischemia time: linear (ref=average time**)	0.0167	0.0100	0.0950
Ischemia time: missing (ref=average time**)	0.1701	0.0650	0.0088
Ischemia time: quadratic (ref=average time**)	-0.0010	0.0006	0.0981
Recipient age: 18-34 (ref=35-49)	-0.0987	0.2355	0.6750
Recipient age: 50-64 (ref=35-49)	0.0589	0.1064	0.5798
Recipient age: 65+ (ref=35-49)	0.1301	0.1879	0.4887
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	0.3368	0.0716	<0.0001
Recipient medical condition: in ICU (ref=not hospitalized)	0.1948	0.0786	0.0132
Recipient on life support	0.5367	0.1002	<0.0001
Recipient race: Asian (ref=White)	-0.2473	0.2625	0.3463
Recipient race: Black (ref=White)	0.2797	0.1352	0.0386
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-0.4371	0.3567	0.2204
Recipient age by donor age interaction: 18-34 and 0-17 (ref=35-49 and 35-49)	-0.1267	0.3750	0.7355
Recipient age by donor age interaction: 18-34 and 18-34 (ref=35-49 and 35-49)	-0.0876	0.3216	0.7854
Recipient age by donor age interaction: 18-34 and 50-64 (ref=35-49 and 35-49)	-0.7704	0.3951	0.0512
Recipient age by donor age interaction: 18-34 and 65+ (ref=35-49 and 35-49)	0.6188	0.4257	0.1461
Recipient age by donor age interaction: 50-64 and 0-17 (ref=35-49 and 35-49)	0.1698	0.1926	0.3780
Recipient age by donor age interaction: 50-64 and 18-34 (ref=35-49 and 35-49)	0.1361	0.1517	0.3696
Recipient age by donor age interaction: 50-64 and 50-64 (ref=35-49 and 35-49)	-0.1118	0.1517	0.4612
Recipient age by donor age interaction: 50-64 and 65+ (ref=35-49 and 35-49)	0.3111	0.2091	0.1367
Recipient age by donor age interaction: 65+ and 0-17 (ref=35-49 and 35-49)	0.6179	0.3022	0.0409
Recipient age by donor age interaction: 65+ and 18-34 (ref=35-49 and 35-49)	0.1531	0.2711	0.5723
Recipient age by donor age interaction: 65+ and 50-64 (ref=35-49 and 35-49)	0.2682	0.2488	0.2812
Recipient age by donor age interaction: 65+ and 65+ (ref=35-49 and 35-49)	0.4504	0.2912	0.1220
Recipient age by recipient race interaction: 18-34 and Asian (ref=35-49 and White)	-0.9972	1.0466	0.3407
Recipient age by recipient race interaction: 18-34 and Black (ref=35-49 and White)	-0.4107	0.3097	0.1848
Recipient age by recipient race interaction: 18-34 and multi-racial/other/unknown/missing (ref=35-49 and White)	-9.3012	95.7459	0.9226
Recipient age by recipient race interaction: 50-64 and Asian (ref=35-49 and White)	0.2616	0.3155	0.4070
Recipient age by recipient race interaction: 50-64 and Black (ref=35-49 and White)	0.1557	0.1920	0.4175
Recipient age by recipient race interaction: 50-64 and multi-racial/other/unknown/missing (ref=35-49 and White)	0.4831	0.4480	0.2809
Recipient age by recipient race interaction: 65+ and Asian (ref=35-49 and White)	-0.2590	0.5726	0.6511
Recipient age by recipient race interaction: 65+ and Black (ref=35-49 and White)	0.0834	0.3567	0.8151
Recipient age by recipient race interaction: 65+ and multi-racial/other/unknown/missing (ref=35-49 and White)	0.4068	0.6860	0.5532


* Reference for diagnosis group is non-cholestatic cirrhosis.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Patient Survival Model Description
1 Month after First Transplant
Organ: Liver
Pediatric (Age 0-17)

97.8% alive at 1 Month when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Diagnosis: AHN*	0.1207	0.4544	0.7904
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.3706	1.0436	0.7225
Diagnosis: Malignant Neoplasms*	-0.5330	1.0396	0.6082
Diagnosis: Metabolic Diseases*	-1.9329	0.8048	0.0163
Diagnosis: Non-Cholestatic Cirrhosis*	-1.5556	0.8519	0.0679
Diagnosis: Other/Missing*	-1.2180	0.6020	0.0430
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	0.8211	1.0799	0.4471
Donor: cadaveric COD anoxia (ref=COD Head trauma)	-0.6359	0.5039	0.2069
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.8946	0.3632	0.0138
Donor: cadaveric COD other (ref=COD Head trauma)	0.2492	0.7503	0.7398
Ischemia time: linear (ref=average time**)	0.1289	0.0798	0.1063
Ischemia time: missing (ref=average time**)	-0.3057	0.7601	0.6876
Ischemia time: quadratic (ref=average time**)	-0.0039	0.0045	0.3944
Partial/Split Liver Transplant	0.1576	0.3422	0.6451
Recipient age: 0-1 (ref=2-10)	1.0980	0.5111	0.0317
Recipient age: 11-17 (ref=2-10)	0.2977	0.5714	0.6024
Recipient medical condition: hospitalized not in ICU (ref=not hospitalized)	-1.0156	0.8133	0.2118
Recipient medical condition: in ICU (ref=not hospitalized)	-0.2139	0.4893	0.6619
Recipient on life support	2.0583	0.4309	<0.0001
Recipient race: Asian (ref=White)	-10.6916	875.6253	0.9903
Recipient race: Black (ref=White)	0.8619	0.7382	0.2430
Recipient race: Multi-racial, other, unknown or missing (ref=White)	-11.8467	1089.5190	0.9913
Ischemia time by recipient medical condition interaction: ischemia time and hospitalized not in ICU (ref=avg time** and not hospitalized)	-0.0058	0.1491	0.9692
Ischemia time by recipient medical condition interaction: ischemia time and in ICU (ref=avg time** and not hospitalized)	0.0186	0.0956	0.8453
Ischemia time by recipient medical condition interaction: missing ischemia time and hospitalized not in ICU (ref=avg time** and not hospitalized)	-15.0125	6119.6876	0.9980
Ischemia time by recipient medical condition interaction: missing ischemia time and in ICU (ref=avg time** and not hospitalized)	1.8536	0.9148	0.0427
Recipient age by recipient race interaction: 0-1 and Asian (ref=2-10 and white)	11.7396	875.6254	0.9893
Recipient age by recipient race interaction: 0-1 and Black (ref=2-10 and white)	-0.6779	0.8605	0.4308
Recipient age by recipient race interaction: 0-1 and multi-racial/other/unknown/missing (ref=2-10 and white)	-2.5511	2727.6601	0.9993
Recipient age by recipient race interaction: 11-17 and Asian (ref=2-10 and White)	-3.3527	2204.0249	0.9988
Recipient age by recipient race interaction: 11-17 and Black (ref=2-10 and White)	-2.0468	1.2959	0.1142
Recipient age by recipient race interaction: 11-17 and multi-racial/other/unknown/missing (ref=2-10 and White)	-4.0488	4405.9938	0.9993


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Patient Survival Model Description
1 Year after First Transplant
Organ: Liver
Pediatric (Age 0-17)

92.6% alive at 1 Year when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

ABO compatibility: compatible (ref=equal)	-0.0167	0.2827	0.9530
ABO compatibility: incompatible (ref=equal)	0.0482	0.4879	0.9213
Diagnosis: AHN*	0.0695	0.3208	0.8284
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	-0.6615	0.7297	0.3646
Diagnosis: Malignant Neoplasms*	0.4223	0.4820	0.3809
Diagnosis: Metabolic Diseases*	-0.8332	0.4511	0.0648
Diagnosis: Non-Cholestatic Cirrhosis*	-1.0812	0.5390	0.0448
Diagnosis: Other/Missing*	-0.2680	0.3460	0.4387
Donor Hispanic/Latino	-0.2359	0.3249	0.4677
Donor: cadaveric COD CNS tumor (ref=COD Head trauma)	0.4276	1.0253	0.6767
Donor: cadaveric COD anoxia (ref=COD Head trauma)	-0.0227	0.3314	0.9454
Donor: cadaveric COD cerebrovascular/stroke (ref=COD Head trauma)	0.5637	0.2718	0.0381
Donor: cadaveric COD other (ref=COD Head trauma)	0.3495	0.4406	0.4276
Partial/Split Liver Transplant	0.4322	0.2338	0.0645
Recipient on life support	1.3795	0.2698	<0.0001


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

Deceased Donor Patient Survival Model Description
3 Years after First Transplant
Organ: Liver
Pediatric (Age 0-17)

91.3% alive at 3 Years when all covariates=0.
Patient Characteristic Covariates	beta	standard error	p-value

Creatinine > 2	-0.0248	0.5552	0.9644
Diagnosis: AHN*	0.3652	0.2600	0.1603
Diagnosis: Cholestatic Liver Disease/Cirrhosis*	0.4560	0.5019	0.3636
Diagnosis: Malignant Neoplasms*	0.8918	0.3537	0.0117
Diagnosis: Metabolic Diseases*	0.1857	0.3098	0.5488
Diagnosis: Non-Cholestatic Cirrhosis*	0.3600	0.3594	0.3165
Diagnosis: Other/Missing*	0.7162	0.2962	0.0156
Donor age: 0-17 (ref=35-49)	0.0537	0.4031	0.8939
Donor age: 18-34 (ref=35-49)	0.1988	0.4344	0.6472
Donor age: 50-64 (ref=35-49)	0.8263	0.5895	0.1610
Donor age: 65+ (ref=35-49)	-12.0872	413.4361	0.9767
Ischemia time: linear (ref=average time**)	0.2516	0.1321	0.0568
Ischemia time: missing (ref=average time**)	0.7129	0.6984	0.3073
Ischemia time: quadratic (ref=average time**)	-0.0043	0.0059	0.4653
Recipient age: 0-1 (ref=2-10)	0.6427	0.2181	0.0032
Recipient age: 11-17 (ref=2-10)	-0.2823	0.2820	0.3169
Recipient on life support	1.1012	0.2051	<0.0001
Donor age by ischemia time interaction: 0-17 and ischemia time (ref=35-49 and avg ischemia time**)	-0.2438	0.1362	0.0734
Donor age by ischemia time interaction: 0-17 and missing ischemia time (ref=35-49 and avg ischemia time**)	-1.0245	0.7656	0.1809
Donor age by ischemia time interaction: 18-34 and ischemia time (ref=35-49 and avg ischemia time**)	-0.3460	0.1469	0.0185
Donor age by ischemia time interaction: 18-34 and missing ischemia time (ref=35-49 and avg ischemia time**)	0.1678	0.8235	0.8385
Donor age by ischemia time interaction: 50-64 and ischemia time (ref=35-49 and avg ischemia time**)	-0.1711	0.1905	0.3691
Donor age by ischemia time interaction: 50-64 and missing ischemia time (ref=35-49 and avg ischemia time**)	0.0572	1.0235	0.9554
Donor age by ischemia time interaction: 65+ and ischemia time (ref=35-49 and avg ischemia time**)	-0.2248	83.7115	0.9979
Donor age by ischemia time interaction: 65+ and missing ischemia time (ref=35-49 and avg ischemia time**)	-1.7251	1155.6323	0.9988


* Reference for diagnosis group is biliary atresia.
** Ischemia time is centered on 8.01 hours.

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