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Table 9.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1997 to 2006

Recipients with Liver Transplants

  Transplant Year
1997 1998 1999 2000 2001 2002 2003 2004 2005 2006
Transplants 4,188 4,516 4,751 4,997 5,195 5,332 5,673 6,170 6,443 6,650
Functioning Graft at 1 Year PostTx 3,182 3,483 3,656 3,900 4,096 4,308 4,582 5,015 5,130 5,441
With Maintenance Use Recorded at 1 Year PostTx 649 2,258 3,409 3,715 4,028 4,211 4,445 4,899 5,003 5,245
CyA 1.1% 3.6% 4.2% 3.1% 2.5% 2.5% 1.9% 1.9% 1.7% 1.9%
Tac 17.3% 19.4% 20.5% 23.6% 28.9% 31.3% 30.1% 28.4% 28.6% 26.6%
--- + MMF/MPA 0.2% 0.1% 0.1% 0.0% 0.1% 0.2% 0.4% 0.3% 0.3% 0.4%
CyA + MMF/MPA 0.6% 2.3% 1.6% 1.3% 1.4% 1.6% 1.9% 2.4% 2.9% 3.0%
Tac + MMF/MPA 1.8% 4.8% 5.5% 7.1% 7.3% 10.1% 13.7% 15.2% 18.1% 22.0%
--- + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet 0.2% 0.2% 0.2% 0.1% 0.1% 0.0% 0.1% 0.2% 0.0% 0.0%
Tac + OtherAntimet 0.5% 0.6% 0.3% 0.5% 0.2% 0.5% 0.3% 0.6% 0.1% 0.2%
--- + MMF/MPA + OtherAntimet 0.2% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + MMF/MPA + OtherAntimet 0.5% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
--- + Siro/Evero 0.0% 0.1% 0.2% 0.8% 1.0% 1.7% 1.5% 2.0% 2.0% 1.9%
CyA + Siro/Evero 0.0% 0.3% 0.1% 0.9% 0.5% 0.3% 0.4% 0.3% 0.5% 0.3%
Tac + Siro/Evero 0.2% 0.0% 0.4% 2.4% 2.5% 2.3% 2.4% 2.9% 2.1% 1.2%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.2% 0.4% 1.0% 1.1% 1.3% 2.4% 2.2%
CyA + MMF/MPA + Siro/Evero 0.0% 0.0% 0.1% 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.0%
Tac + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.2% 0.1% 0.2% 0.3% 0.2% 0.2% 0.2%
--- + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.0%
Tac + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
--- + Steroids 0.5% 1.8% 1.8% 1.6% 0.6% 0.8% 0.5% 0.4% 0.3% 0.2%
CyA + Steroids 9.7% 11.1% 10.3% 5.8% 2.9% 2.3% 2.0% 1.7% 1.2% 1.2%
Tac + Steroids 31.4% 32.9% 30.5% 26.8% 22.7% 22.3% 20.9% 18.1% 15.8% 15.0%
--- + MMF/MPA + Steroids 0.5% 0.3% 0.4% 0.3% 0.3% 0.4% 0.4% 0.4% 0.4% 0.5%
CyA + MMF/MPA + Steroids 4.8% 4.4% 5.0% 4.0% 3.2% 2.0% 2.1% 2.0% 1.8% 1.5%
Tac + MMF/MPA + Steroids 9.6% 8.8% 10.4% 10.8% 13.2% 12.6% 14.1% 15.5% 16.8% 17.4%
--- + OtherAntimet + Steroids 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0% 0.0%
CyA + OtherAntimet + Steroids 6.6% 2.4% 2.5% 1.7% 0.8% 0.3% 0.2% 0.3% 0.1% 0.0%
Tac + OtherAntimet + Steroids 3.4% 2.9% 1.4% 1.1% 1.4% 1.4% 1.0% 0.5% 0.3% 0.2%
--- + Siro/Evero + Steroids 0.0% 0.1% 0.1% 0.3% 1.0% 0.9% 0.8% 1.6% 1.3% 1.1%
CyA + Siro/Evero + Steroids 0.0% 0.3% 0.3% 0.3% 0.4% 0.3% 0.3% 0.1% 0.1% 0.0%
Tac + Siro/Evero + Steroids 0.0% 0.1% 0.6% 3.0% 2.3% 2.1% 1.5% 1.5% 1.2% 0.9%
Other Regimen 11.2% 3.2% 3.6% 4.3% 5.8% 2.7% 2.1% 1.8% 1.6% 1.8%


Source: OPTN/SRTR Data as of May 1, 2008.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.



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