Table 8.6h

Persistency of Discharge Regimen by Follow-up Period, 2001 to 2005

Recipients with Kidney-Pancreas Transplants

  Year of Transplant
2001 2002 2003 2004 2005
Discharge Regimen (w/ or w/o Steroid Use) CyA+Aza At Discharge (N) 1 - - 1 -
At Discharge (%) 100.0% - - 100.0% -
6 Months PostTx (%) 0.0% - - 100.0% -
1 Year PostTx (%) 0.0% - - 100.0% -
2 Years PostTx (%) 0.0% - - - -
3 Years PostTx (%) 0.0% - - - -
CyA+MMF At Discharge (N) 73 61 45 14 22
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 80.8% 78.4% 75.1% 57.1% 90.9%
1 Year PostTx (%) 72.6% 75.0% 59.2% 50.0% 76.8%
2 Years PostTx (%) 62.8% 70.0% 56.9% 41.7% -
3 Years PostTx (%) 58.6% 64.8% 54.3% - -
CyA+Siro At Discharge (N) 14 5 26 32 33
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 85.7% 60.0% 80.8% 78.1% 68.0%
1 Year PostTx (%) 85.7% 20.0% 65.4% 50.0% 53.2%
2 Years PostTx (%) 78.6% 0.0% 61.5% 43.1% 35.5%
3 Years PostTx (%) 70.7% 0.0% 61.5% - -
Siro+MMF At Discharge (N) 10 5 30 40 4
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 70.0% 0.0% 66.7% 80.0% 100.0%
1 Year PostTx (%) 60.0% 0.0% 60.0% 65.0% 75.0%
2 Years PostTx (%) 60.0% 0.0% 46.7% 52.0% -
3 Years PostTx (%) 40.0% 0.0% 42.4% - -
Tac+Aza At Discharge (N) 1 5 6 2 -
At Discharge (%) 100.0% 100.0% 100.0% 100.0% -
6 Months PostTx (%) 100.0% 60.0% 50.0% 100.0% -
1 Year PostTx (%) 100.0% 60.0% 33.3% 100.0% -
2 Years PostTx (%) - 60.0% 33.3% 100.0% -
3 Years PostTx (%) - 60.0% 33.3% - -
Tac+MMF At Discharge (N) 530 580 562 611 658
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 84.0% 82.7% 78.8% 85.0% 90.3%
1 Year PostTx (%) 75.7% 72.1% 71.2% 78.5% 85.6%
2 Years PostTx (%) 65.9% 65.9% 66.9% 73.4% 80.3%
3 Years PostTx (%) 59.1% 62.2% 59.9% 60.1% -
Tac+Siro At Discharge (N) 110 105 71 51 77
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 83.4% 77.1% 80.3% 79.3% 81.8%
1 Year PostTx (%) 76.7% 70.5% 64.8% 70.7% 79.3%
2 Years PostTx (%) 67.7% 59.9% 57.6% 53.0% 79.3%
3 Years PostTx (%) 50.6% 51.8% 43.6% 53.0% -


Source: OPTN/SRTR Data as of May 1, 2007.

Regimen change is defined as being on different drug combination at follow-up comparing to discharge, or indication of conflicting regimen (CyA vs. Tac; MMF/MPA vs. Aza; Siro vs. Evero) during follow-up period, or graft failure/death. Addition or deletion of steroids is not considered a regimen change.Rates are calculated for the most common discharge regimens.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.

See Technical Notes for further details.