Table 15.7

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1998 to 2004

Recipients with Kidney Transplants

  Transplant Year
1998 1999 2000 2001 2002 2003 2004
Transplants 12,452 12,760 13,612 14,266 14,779 15,137 16,004
Functioning Graft at 2 Years PostTx 9,960 10,202 11,063 11,831 12,314 12,639 13,304
With Maintenance Use Recorded at 2 Years PostTx 9,405 9,685 10,832 11,528 11,997 12,352 12,985
--- + MMF/MPA 0.1% 0.1% 0.1% 0.1% 0.1% 0.3% 0.3%
--- + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.2% 0.5% 0.7% 1.4% 1.9%
--- + MMF/MPA + Steroids 1.6% 1.9% 1.4% 1.3% 1.3% 1.1% 1.2%
--- + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
--- + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
--- + OtherAntimet + Steroids 0.2% 0.1% 0.1% 0.1% 0.1% 0.1% 0.1%
--- + Siro/Evero 0.0% 0.0% 0.2% 0.3% 0.2% 0.2% 0.2%
--- + Siro/Evero + Steroids 0.2% 0.5% 0.7% 1.0% 0.7% 1.0% 0.9%
--- + Steroids 0.6% 0.7% 0.3% 0.5% 0.4% 0.5% 0.3%
CyA 0.3% 0.7% 0.2% 0.2% 0.1% 0.1% 0.1%
CyA + MMF/MPA 1.3% 1.1% 1.4% 1.5% 1.7% 2.3% 2.3%
CyA + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + MMF/MPA + Siro/Evero 0.0% 0.0% 0.1% 0.1% 0.0% 0.1% 0.0%
CyA + MMF/MPA + Steroids 39.7% 36.2% 31.0% 22.8% 18.5% 14.0% 12.0%
CyA + OtherAntimet 0.4% 0.2% 0.1% 0.1% 0.1% 0.0% 0.1%
CyA + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet + Steroids 6.6% 4.6% 2.9% 1.5% 0.7% 0.5% 0.3%
CyA + Siro/Evero 0.6% 0.2% 0.3% 0.4% 0.8% 0.8% 0.8%
CyA + Siro/Evero + Steroids 2.3% 2.3% 3.7% 2.9% 2.5% 1.9% 1.3%
CyA + Steroids 8.0% 6.9% 4.1% 2.4% 1.5% 1.4% 0.9%
Tac 0.8% 0.8% 0.8% 1.5% 1.8% 1.9% 2.3%
Tac + MMF/MPA 1.8% 2.2% 2.9% 4.4% 6.5% 9.9% 15.5%
Tac + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + MMF/MPA + Siro/Evero 0.0% 0.1% 0.2% 0.3% 0.5% 0.8% 0.7%
Tac + MMF/MPA + Steroids 23.2% 27.4% 29.7% 35.0% 38.6% 41.3% 40.1%
Tac + OtherAntimet 0.3% 0.2% 0.2% 0.2% 0.3% 0.2% 0.3%
Tac + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + OtherAntimet + Steroids 2.6% 2.1% 2.0% 2.0% 1.6% 1.4% 1.3%
Tac + Siro/Evero 0.0% 0.1% 0.9% 2.1% 2.4% 2.7% 2.1%
Tac + Siro/Evero + Steroids 0.5% 1.4% 4.8% 6.5% 5.6% 4.4% 3.2%
Tac + Steroids 6.5% 7.2% 7.4% 6.5% 6.1% 5.1% 4.5%
Other Regimen 2.3% 3.0% 4.2% 5.8% 6.9% 6.7% 7.1%


Source: OPTN/SRTR Data as of May 1, 2007.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column.

Transplants prior to year 1998 are not reported due to insufficient reporting of immunosuppressive drug use.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.