Table 15.6

Steroid Withdrawal Rate at Two Years Following Transplantation, 1998 to 2004

Recipients of Heart Transplants

Discharge Regimen Year of Transplant
1998 1999 2000 2001 2002 2003 2004
Total Patients 1,627 1,483 1,561 1,582 1,562 1,457 1,420
Steroids Withdrawn 485 423 474 559 547 556 576
Rate 29.8% 28.5% 30.4% 35.3% 35.0% 38.2% 40.6%
CyA Patients 61 176 66 28 39 22 10
Steroids Withdrawn 22 48 21 9 21 9 5
Rate 36.1% 27.3% 31.8% 32.1% 53.8% 40.9% 50.0%
Tac Patients 31 37 31 56 59 38 30
Steroids Withdrawn 21 21 17 21 27 11 20
Rate 67.7% 56.8% 54.8% 37.5% 45.8% 28.9% 66.7%
CyA+MMF Patients 576 640 906 863 699 676 610
Steroids Withdrawn 150 156 248 268 237 243 239
Rate 26.0% 24.4% 27.4% 31.1% 33.9% 35.9% 39.2%
Tac+MMF Patients 86 95 130 300 364 425 553
Steroids Withdrawn 17 27 39 139 127 172 230
Rate 19.8% 28.4% 30.0% 46.3% 34.9% 40.5% 41.6%
CyA+Aza Patients 650 389 244 162 101 73 61
Steroids Withdrawn 219 128 95 59 28 28 16
Rate 33.7% 32.9% 38.9% 36.4% 27.7% 38.4% 26.2%
Tac+Aza Patients 37 29 32 21 20 19 16
Steroids Withdrawn 12 7 7 5 3 6 5
Rate 32.4% 24.1% 21.9% 23.8% 15.0% 31.6% 31.3%
Siro+MMF Patients - - - 3 5 16 14
Steroids Withdrawn - - - 1 0 4 1
Rate - - - 33.3% 0.0% 25.0% 7.1%
CyA+Siro Patients 1 10 10 3 17 33 2
Steroids Withdrawn 0 5 6 1 13 24 1
Rate 0.0% 50.0% 60.0% 33.3% 76.5% 72.7% 50.0%
Tac+Siro Patients - 0 15 31 97 30 12
Steroids Withdrawn - - 0 4 34 12 10
Rate - - 0.0% 12.9% 35.1% 40.0% 83.3%
Other Regimen Patients 185 107 127 115 161 125 112
Steroids Withdrawn 44 31 41 52 57 47 49
Rate 23.8% 29.0% 32.3% 45.2% 35.4% 37.6% 43.8%


Source: OPTN/SRTR Data as of May 1, 2007.

Includes patients receiving first transplants of any organ with steroid use at transplant discharge, and who have a functioning graft and maintenance drug use two years after transplantation.

Transplants prior to year 1998 are not reported due to insufficient reporting of immunosuppressive drug use.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.