Table 15.5a

Steroid Withdrawal Rate at One Year Following Transplantation, 1999 to 2005

Recipients of Deceased Donor Livers

Discharge Regimen Year of Transplant
1999 2000 2001 2002 2003 2004 2005
Total Patients 2,684 2,894 2,995 3,234 3,202 3,443 3,373
Steroids Withdrawn 860 1,146 1,371 1,666 1,632 1,752 1,841
Rate 32.0% 39.6% 45.8% 51.5% 51.0% 50.9% 54.6%
CyA Patients 288 193 92 75 51 42 41
Steroids Withdrawn 70 45 41 41 17 19 22
Rate 24.3% 23.3% 44.6% 54.7% 33.3% 45.2% 53.7%
Tac Patients 1,075 995 1,074 1,269 1,139 1,159 1,038
Steroids Withdrawn 427 467 524 701 596 577 554
Rate 39.7% 46.9% 48.8% 55.2% 52.3% 49.8% 53.4%
CyA+MMF Patients 271 224 187 150 139 139 144
Steroids Withdrawn 59 52 59 63 57 68 80
Rate 21.8% 23.2% 31.6% 42.0% 41.0% 48.9% 55.6%
Tac+MMF Patients 703 956 1,172 1,330 1,545 1,765 1,911
Steroids Withdrawn 239 391 545 683 824 930 1,067
Rate 34.0% 40.9% 46.5% 51.4% 53.3% 52.7% 55.8%
CyA+Aza Patients 124 97 47 44 1 24 12
Steroids Withdrawn 3 15 4 12 0 7 4
Rate 2.4% 15.5% 8.5% 27.3% 0.0% 29.2% 33.3%
Tac+Aza Patients 88 64 59 77 80 26 3
Steroids Withdrawn 11 11 15 17 15 14 0
Rate 12.5% 17.2% 25.4% 22.1% 18.8% 53.8% 0.0%
Siro+MMF Patients 2 27 39 34 32 31 30
Steroids Withdrawn 0 11 16 20 16 14 17
Rate 0.0% 40.7% 41.0% 58.8% 50.0% 45.2% 56.7%
CyA+Siro Patients 3 13 8 21 18 19 17
Steroids Withdrawn 1 7 3 14 9 14 13
Rate 33.3% 53.8% 37.5% 66.7% 50.0% 73.7% 76.5%
Tac+Siro Patients 4 135 134 85 42 52 38
Steroids Withdrawn 2 63 67 57 24 23 19
Rate 50.0% 46.7% 50.0% 67.1% 57.1% 44.2% 50.0%
Other Regimen Patients 126 190 183 149 155 186 139
Steroids Withdrawn 48 84 97 58 74 86 65
Rate 38.1% 44.2% 53.0% 38.9% 47.7% 46.2% 46.8%


Source: OPTN/SRTR Data as of May 1, 2007.

Includes patients receiving first transplants of any organ with steroid use at transplant discharge, and who have a functioning graft and maintenance drug use one year after transplantation.

Transplants prior to year 1999 are not reported due to insufficient reporting of immunosuppressive drug use.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.