Table 12.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1996 to 2005

Recipients with Lung Transplants

  Transplant Year
1996 1997 1998 1999 2000 2001 2002 2003 2004 2005
Transplants 837 948 893 922 977 1,083 1,054 1,099 1,185 1,407
Functioning Graft at 1 Year PostTx 565 673 631 667 735 805 832 895 987 1,127
With Maintenance Use Recorded at 1 Year PostTx 55 88 325 620 695 767 808 864 978 1,113
--- + MMF/MPA 0.0% 0.0% 0.3% 0.3% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.0% 0.0% 0.1%
--- + MMF/MPA + Steroids 0.0% 0.0% 0.3% 0.0% 0.4% 0.3% 0.1% 0.3% 0.2% 0.2%
--- + OtherAntimet 1.8% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0%
--- + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.2% 0.0% 0.0% 0.0%
--- + OtherAntimet + Steroids 1.8% 1.1% 0.3% 0.2% 0.4% 0.3% 0.2% 0.3% 0.1% 0.1%
--- + Siro/Evero 0.0% 0.0% 0.0% 0.3% 0.0% 0.3% 0.1% 0.1% 0.0% 0.0%
--- + Siro/Evero + Steroids 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.7% 0.2% 0.2% 0.4%
--- + Steroids 1.8% 3.4% 0.9% 0.5% 0.4% 0.5% 0.4% 0.7% 0.4% 0.4%
CyA 0.0% 0.0% 0.0% 0.0% 0.4% 0.0% 0.1% 0.0% 0.0% 0.0%
CyA + MMF/MPA 1.8% 1.1% 0.0% 0.0% 0.1% 0.4% 0.1% 0.3% 0.0% 0.0%
CyA + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + MMF/MPA + Steroids 7.3% 17.0% 15.4% 17.4% 14.0% 14.0% 10.8% 8.9% 7.6% 7.5%
CyA + OtherAntimet 0.0% 0.0% 0.3% 0.2% 0.1% 0.1% 0.4% 0.2% 0.0% 0.0%
CyA + OtherAntimet + Steroids 30.9% 30.7% 32.3% 26.8% 22.9% 12.4% 8.2% 8.8% 6.2% 4.9%
CyA + Siro/Evero + Steroids 0.0% 0.0% 0.3% 1.8% 1.3% 0.9% 0.9% 0.5% 0.3% 0.1%
CyA + Steroids 9.1% 6.8% 4.3% 5.6% 3.5% 2.1% 1.6% 2.2% 1.1% 1.3%
Tac 0.0% 0.0% 0.3% 0.2% 0.0% 0.3% 0.6% 0.3% 0.1% 0.0%
Tac + MMF/MPA 1.8% 0.0% 0.6% 0.3% 1.3% 0.5% 1.0% 0.5% 0.4% 0.5%
Tac + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.1%
Tac + MMF/MPA + Steroids 12.7% 18.2% 17.5% 17.1% 26.6% 29.7% 32.7% 34.3% 40.8% 45.9%
Tac + OtherAntimet 0.0% 0.0% 0.0% 0.2% 0.1% 0.1% 1.2% 0.5% 0.2% 0.1%
Tac + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.0%
Tac + OtherAntimet + Steroids 18.2% 10.2% 18.2% 17.4% 16.3% 17.3% 20.0% 22.9% 23.0% 20.5%
Tac + Siro/Evero 0.0% 0.0% 0.0% 0.2% 0.1% 0.1% 0.2% 0.1% 0.0% 0.1%
Tac + Siro/Evero + Steroids 0.0% 0.0% 0.0% 3.2% 2.7% 3.5% 6.3% 3.9% 4.2% 3.7%
Tac + Steroids 3.6% 2.3% 5.5% 6.5% 5.5% 9.9% 7.3% 8.0% 9.9% 9.7%
Other Regimen 9.1% 9.1% 3.4% 1.9% 3.5% 7.0% 6.6% 6.5% 5.1% 4.4%


Source: OPTN/SRTR Data as of May 1, 2007.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.