Table 11.6h

Persistency of Discharge Regimen by Follow-up Period, 2001 to 2005

Recipients with Heart Transplants

  Year of Transplant
2001 2002 2003 2004 2005
Discharge Regimen (w/ or w/o Steroid Use) CyA+Aza At Discharge (N) 206 139 94 84 49
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 48.3% 39.0% 45.2% 63.1% 71.7%
2 Years PostTx (%) 27.3% 32.3% 34.6% 40.5% 35.9%
3 Years PostTx (%) 22.5% 25.0% 29.4% 40.5% -
CyA+MMF At Discharge (N) 1,036 838 827 750 636
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 73.7% 67.3% 67.5% 77.9% 83.1%
2 Years PostTx (%) 55.9% 53.0% 55.1% 62.2% 72.3%
3 Years PostTx (%) 48.6% 45.6% 47.1% 48.8% -
CyA+Siro At Discharge (N) 3 19 39 2 2
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 66.7% 63.2% 51.3% 50.0% 100.0%
2 Years PostTx (%) 0.0% 57.9% 38.5% 50.0% -
3 Years PostTx (%) 0.0% 47.4% 33.0% - -
Siro+MMF At Discharge (N) 4 7 19 24 16
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 25.0% 28.6% 63.2% 75.0% 68.2%
2 Years PostTx (%) 25.0% 28.6% 52.6% 46.9% -
3 Years PostTx (%) 25.0% 28.6% 42.1% - -
Tac+Aza At Discharge (N) 27 27 26 23 19
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 51.9% 40.7% 60.0% 78.3% 51.7%
2 Years PostTx (%) 37.0% 37.0% 38.8% 65.7% 51.7%
3 Years PostTx (%) 25.9% 25.9% 19.4% - -
Tac+MMF At Discharge (N) 390 483 571 720 941
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 75.7% 75.4% 76.8% 83.8% 85.9%
2 Years PostTx (%) 62.2% 62.8% 68.3% 73.0% 72.5%
3 Years PostTx (%) 56.4% 55.0% 62.1% 68.0% -
Tac+Siro At Discharge (N) 47 111 36 19 23
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 61.7% 65.5% 66.7% 55.7% 78.4%
2 Years PostTx (%) 46.4% 55.5% 60.3% 47.8% 39.2%
3 Years PostTx (%) 41.5% 47.2% 51.0% - -


Source: OPTN/SRTR Data as of May 1, 2007.

Regimen change is defined as being on different drug combination at follow-up comparing to discharge, or indication of conflicting regimen (CyA vs. Tac; MMF/MPA vs. Aza; Siro vs. Evero) during follow-up period, or graft failure/death. Addition or deletion of steroids is not considered a regimen change.Rates are calculated for the most common discharge regimens.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.

See Technical Notes for further details.