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Table 1.9a

Immunosuppression Use by Organ in 2007 and 2008

  Organ
Heart-Lung Heart Intestine Kidney KP Liver Lung PAK PTA
Transplants (2008)   27 2,163 185 16,517 836 6,318 1,478 214 223
Tx With Immunosuppression Info at Discharge   22 2,110 182 16,250 823 6,125 1,436 206 219
Induction Drug Reported 72.7% 52.3% 59.9% 81.5% 83.4% 26.6% 62.7% 79.6% 73.1%
Induction Drugs Atgam/NRATG/NRATS 13.6% 6.5% 0.0% 1.5% 1.5% 1.1% 7.1% 1.0% 1.4%
OKT3 0.0% 1.4% 15.4% 1.0% 1.0% 2.5% 0.7% 1.0% 6.4%
Thymoglobulin 0.0% 18.1% 33.5% 44.8% 59.8% 10.3% 4.5% 51.9% 49.8%
Zenapax 40.9% 11.1% 8.2% 10.9% 6.1% 7.9% 14.0% 4.4% 6.8%
Simulect 4.5% 14.0% 0.5% 17.8% 8.4% 6.7% 28.8% 8.3% 4.6%
Campath 13.6% 3.4% 18.1% 10.7% 9.8% 1.0% 9.2% 15.0% 11.4%
Tx With Immunosuppression Info and Functioning Graft at Discharge   20 2,026 167 16,000 815 5,826 1,358 192 201
Maintenance at Discharge Corticosteroids Use   100.0% 87.4% 78.4% 66.2% 70.1% 80.0% 98.2% 59.9% 56.7%
Steroids 100.0% 87.4% 78.4% 66.2% 70.1% 80.0% 98.2% 59.9% 56.7%
Calcineurin Inhibitor Use   100.0% 98.7% 100.0% 95.9% 98.4% 98.0% 98.9% 96.9% 99.0%
Cyclosporine 10.0% 25.6% 0.6% 7.6% 4.4% 7.0% 8.4% 3.6% 1.5%
Tacrolimus 90.0% 72.5% 98.8% 87.8% 93.3% 90.4% 89.3% 92.7% 97.5%
Everolimus 0.0% 0.6% 0.6% 0.5% 0.7% 0.6% 1.2% 0.5% 0.0%
Antimetabolite Use   95.0% 92.5% 24.6% 93.4% 91.2% 77.0% 91.4% 93.8% 62.2%
Mycophenolate Mofetil 85.0% 87.1% 24.0% 74.1% 72.5% 71.3% 54.3% 79.2% 55.7%
Mycophenolate Sodium 5.0% 2.7% 0.0% 18.5% 18.5% 5.3% 8.7% 13.0% 6.0%
Azathioprine 5.0% 2.8% 0.6% 0.8% 0.1% 0.4% 28.4% 1.0% 0.5%
Leflunomide 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.5% 0.0%
mTOR Inhibitor Use   0.0% 3.4% 9.6% 4.1% 8.0% 2.2% 0.4% 7.8% 10.9%
Sirolimus 0.0% 1.0% 9.6% 4.1% 8.0% 2.1% 0.4% 7.8% 10.9%
Everolimus 0.0% 2.4% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Transplants (2007)   31 2,209 198 16,630 862 6,494 1,471 261 208
Tx With Maintenance Use at 1yr PostTx   26 1,896 139 14,693 755 5,131 1,150 206 150
Maintenance at 1yr PostTx Corticosteroids Use   100.0% 66.0% 68.3% 64.1% 67.5% 35.1% 98.6% 55.3% 53.3%
Steroids 100.0% 66.0% 68.3% 64.1% 67.5% 35.1% 98.6% 55.3% 53.3%
Calcineurin Inhibitor Use   100.0% 97.1% 98.6% 94.1% 97.9% 92.7% 98.2% 97.1% 96.7%
Cyclosporine 7.7% 27.8% 1.4% 9.7% 6.9% 8.2% 9.8% 5.3% 2.7%
Tacrolimus 92.3% 68.9% 96.4% 84.0% 90.6% 84.2% 87.8% 90.8% 94.0%
Everolimus 0.0% 0.4% 0.7% 0.5% 0.4% 0.4% 0.5% 1.0% 0.0%
Antimetabolite Use   57.7% 88.1% 10.1% 88.4% 84.8% 49.6% 80.2% 87.9% 56.7%
Mycophenolate Mofetil 46.2% 75.7% 8.6% 65.6% 62.1% 43.0% 48.8% 70.4% 46.7%
Mycophenolate Sodium 3.8% 6.9% 0.0% 20.7% 21.2% 5.8% 8.8% 15.0% 8.0%
Azathioprine 7.7% 5.4% 1.4% 1.4% 1.1% 0.8% 22.5% 1.0% 2.0%
Leflunomide 0.0% 0.1% 0.0% 0.7% 0.4% 0.0% 0.1% 1.5% 0.0%
mTOR Inhibitor Use   3.8% 9.3% 6.5% 8.3% 13.9% 8.3% 6.6% 18.0% 20.0%
Sirolimus 3.8% 6.9% 6.5% 8.0% 13.9% 8.3% 6.6% 18.0% 20.0%
Everolimus 0.0% 2.5% 0.0% 0.3% 0.0% 0.0% 0.0% 0.0% 0.0%


Source: OPTN/SRTR Data as of May 4, 2009.

Individual drug percentages will not necessarily add up to the drug category percentages, as patients may be prescribed more than one drug within the same category.

Induction drugs include any reported antilymphocyte antibodies and antibodies directed against lymphocyte receptors.



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